Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism.

Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Research Abstract Details 

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Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Abstract Text:

Zhengzheng Pan,Haiwei Gu,Nari Talaty,Huanwen Chen,Narasimhamurthy Shanaiah,Bryan E Hainline,R Graham Cooks,Daniel Raftery,

Urine metabolic profiles of patients with inborn errors of metabolism were examined with nuclear magnetic resonance (NMR) and desorption electrospray ionization mass spectrometry (DESI-MS) methods. Spectra obtained from the study of urine samples from individual patients with argininosuccinic aciduria (ASA), classic homocystinuria (HCY), classic methylmalonic acidemia (MMA), maple syrup urine disease (MSUD), phenylketonuria (PKU) and type II tyrosinemia (TYRO) were compared with six control patient urine samples using principal component analysis (PCA). Target molecule spectra were identified from the loading plots of PCA output and compared with known metabolic profiles from the literature and metabolite databases. Results obtained from the two techniques were then correlated to obtain a common list of molecules associated with the different diseases and metabolic pathways. The combined approach discussed here may prove useful in the rapid screening of biological fluids from sick patients and may help to improve the understanding of these rare diseases.

Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Publishing Authors By Initials

Z Pan,H Gu,N Talaty,H Chen,N Shanaiah,BE Hainline,RG Cooks,D Raftery,

For similar fluids and secretions: body fluids: urine research abstracts see: fluids and secretions: body fluids: urine research

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Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Analytical and bioanalytical chemistry

VOLUME: 387

Page Numbers: 539-49

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ISSN: 1618-2642

DAY: 5

MONTH: 07

YEAR: 2006

Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Information

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LANGUAGE: eng

NlmUniqueID: 101134327

Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Keywords Mesh Terms:

KEYWORDS: Urine

MESH TERMS: chemistry

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Grant and Affiliation Information for Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism.

AFFILIATION: Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.

Country: Germany

AGENCY: United States NIGMS

GRANT: 5R01 GM58008-07

ACRONYM: GM

MEDLINETA: Anal Bioanal Chem

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