Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus.

Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. Research Abstract Details 

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Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. Abstract Text:

Timothy J Powell,Tara Strutt,Joyce Reome,Joseph A Hollenbaugh,Alan D Roberts,David L Woodland,Susan L Swain,Richard W Dutton,

We show in this study several novel features of T cell-based heterosubtypic immunity against the influenza A virus in mice. First, T cell-mediated heterosubtypic protection against lethal challenge can be generated by a very low priming dose. Second, it becomes effective within 5-6 days. Third, it provides protection against a very high dose challenge for >70 days. Also novel is the finding that strong, long-lasting, heterosubtypic protection can be elicited by priming with attenuated cold-adapted strains. We demonstrate that priming does not prevent infection of the lungs following challenge, but leads to earlier clearance of the virus and 100% survival after otherwise lethal challenge. Protection is dependent on CD8 T cells, and we show that CD4 and CD8 T cells reactive to conserved epitopes of the core proteins of the challenge virus are present after priming. Our results suggest that intranasal vaccination with cold-adapted, attenuated live virus has the potential to provide effective emergency protection against emerging influenza strains for several months.

Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. Publishing Authors By Initials

TJ Powell,T Strutt,J Reome,JA Hollenbaugh,AD Roberts,DL Woodland,SL Swain,RW Dutton,

For similar proteins: viral proteins: viral structural proteins: nucleocapsid proteins: viral core proteins research abstracts see: proteins: viral proteins: viral structural proteins: nucleocapsid proteins: viral core proteins research

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Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 178

Page Numbers: 1030-8

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Jan

YEAR: 2007

Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. Keywords Mesh Terms:

KEYWORDS: Viral Core Proteins

MESH TERMS: immunology

Chemical & Substance for Abstract: Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. Information

Substance Name: Viral Core Proteins

Registry Number: 0

Grant and Affiliation Information for Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus.

AFFILIATION: Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 063925

ACRONYM: HL

MEDLINETA: J Immunol

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