Primary protein response after ligand photodissociation in carbonmonoxy myoglobin.

Primary protein response after ligand photodissociation in carbonmonoxy myoglobin. Research Abstract Details 

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Primary protein response after ligand photodissociation in carbonmonoxy myoglobin. Abstract Text:

Akira Sato,Ying Gao,Teizo Kitagawa,Yasuhisa Mizutani,Akira Sato,Ying Gao,Teizo Kitagawa,Yasuhisa Mizutani,

Time-resolved UV resonance Raman (UVRR) spectroscopic studies of WT and mutant myoglobin were performed to reveal the dynamics of protein motion after ligand dissociation. After dissociation of carbon monoxide (CO) from the heme, UVRR bands of Tyr showed a decrease in intensity with a time constant of 2 ps. The intensity decrease was followed by intensity recovery with a time constant of 8 ps. On the other hand, UVRR bands of Trp residues located in the A helix showed an intensity decrease that was completed within the instrument response time. The intensity decrease was followed by an intensity recovery with a time constant of approximately 50 ps and lasted up to 1 ns. The time-resolved UVRR study of the myoglobin mutants demonstrated that the hydrophobicity of environments around Trp-14 decreased, whereas that around Trp-7 barely changed in the primary protein response. The present data indicate that displacement of the E helix toward the heme occurs within the instrument response time and that movement of the FG corner takes place with a time constant of 2 ps. The finding that the instantaneous motion of the E helix strongly suggests a mechanism in which protein structural changes are propagated from the heme to the A helix through the E helix motion.

Primary protein response after ligand photodissociation in carbonmonoxy myoglobin. Publishing Authors By Initials

A Sato,Y Gao,T Kitagawa,Y Mizutani,A Sato,Y Gao,T Kitagawa,Y Mizutani,

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Primary protein response after ligand photodissociation in carbonmonoxy myoglobin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 9627-32

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 21

MONTH: 05

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Primary protein response after ligand photodissociation in carbonmonoxy myoglobin.

AFFILIATION: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Honmachi, Kawaguchi 332-0012, Japan.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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