Primary neurons become less susceptible to coxsackievirus B5 following maturation: The correlation with the decreased level of CAR expression on cell surface.

Primary neurons become less susceptible to coxsackievirus B5 following maturation: The correlation with the decreased level of CAR expression on cell surface. Research Abstract Details 

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Primary neurons become less susceptible to coxsackievirus B5 following maturation: The correlation with the decreased level of CAR expression on cell surface. Abstract Text:

Jeonghyun Ahn,Youngmee Jee,Ilseon Seo,Seung Yong Yoon,Donghou Kim,Yoo Kyum Kim,Heuiran Lee,Jeonghyun Ahn,Youngmee Jee,Ilseon Seo,Seung Yong Yoon,DongHou Kim,Yoo Kyum Kim,Heuiran Lee,

Coxsackievirus B (CVB) is one of the major pathogens of aseptic meningitis and meningioencephalitis, particularly in newborn infants. To analyze the influence of neural maturation on susceptibility to CVB infection, we prepared immature and mature neurons from 16-day-old BALB/c embryonic cortex. In contrast to immature neurons, mature neurons were less susceptible to CVB5 infection, as indicated by the decrease of cytopathic features. In mature neurons, progeny virus production was significantly hindered, and virus capsid protein VP1 synthesis and virus genome amplification were concomitantly reduced. In addition, the expression of coxsackievirus and adenovirus receptor (CAR), the major receptor of CVB5, was down-regulated in mature neurons. The antibody treatment specific to CAR significantly attenuated CVB5 susceptibility of immature neurons. These findings demonstrate that mature neurons become less susceptible to CVB by the decrease of CAR level. Thus, the data strongly support the idea that the level of virus receptor in neurons is one of the crucial determinants in the age-dependency of CVB virulence in central nervous system. J. Med. Virol. 80:434-440, 2008. (c) 2008 Wiley-Liss, Inc.

Primary neurons become less susceptible to coxsackievirus B5 following maturation: The correlation with the decreased level of CAR expression on cell surface. Publishing Authors By Initials

J Ahn,Y Jee,I Seo,SY Yoon,D Kim,YK Kim,H Lee,J Ahn,Y Jee,I Seo,SY Yoon,D Kim,YK Kim,H Lee,

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Primary neurons become less susceptible to coxsackievirus B5 following maturation: The correlation with the decreased level of CAR expression on cell surface. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of medical virology

VOLUME: 80

Page Numbers: 434-40

Journal Abbreviation: J. Med. Virol.

ISSN: 0146-6615

DAY: 24

MONTH: Mar

YEAR: 2008

Primary neurons become less susceptible to coxsackievirus B5 following maturation: The correlation with the decreased level of CAR expression on cell surface. Information

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LANGUAGE: eng

NlmUniqueID: 7705876

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Grant and Affiliation Information for Primary neurons become less susceptible to coxsackievirus B5 following maturation: The correlation with the decreased level of CAR expression on cell surface.

AFFILIATION: Department of Microbiology, University of Ulsan College of Medicine, Seoul, Korea.

Country: United States

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MEDLINETA: J Med Virol

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