Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee.

Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. Research Abstract Details 

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Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. Abstract Text:

Raif S Geha,Luigi D Notarangelo,Jean-Laurent Casanova,Helen Chapel,Mary Ellen Conley,Alain Fischer,Lennart ,Shigeaki Nonoyama,Hans D Ochs,Jennifer M Puck,Chaim Roifman,Reinhard Seger,Josiah Wedgwood, ,

Primary immunodeficiency diseases (PIDs) are a genetically heterogeneous group of disorders that affect distinct components of the innate and adaptive immune system, such as neutrophils, macrophages, dendritic cells, complement proteins, natural killer cells, and T and B lymphocytes. The study of these diseases has provided essential insights into the functioning of the immune system. More than 120 distinct genes have been identified, whose abnormalities account for more than 150 different forms of PID. The complexity of the genetic,immunologic, and clinical features of PID has prompted the need for their classification, with the ultimate goal of facilitating diagnosis and treatment. To serve this goal, an international committee of experts has met every 2 years since 1970. In its last meeting in Jackson Hole, Wyo, after 3 days of intense scientific presentations and discussions, the committee has updated the classification of PID, as reported in this article.

Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. Publishing Authors By Initials

RS Geha,LD Notarangelo,JL Casanova,H Chapel,ME Conley,A Fischer,L ,S Nonoyama,HD Ochs,JM Puck,C Roifman,R Seger,J Wedgwood, ,

For similar immune system diseases: immunologic deficiency syndromes research abstracts see: immune system diseases: immunologic deficiency syndromes research

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Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of allergy and clinical immunology

VOLUME: 120

Page Numbers: 776-94

Journal Abbreviation: J. Allergy Clin. Immunol.

ISSN: 0091-6749

DAY: 3

MONTH: Oct

YEAR: 2007

Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. Information

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LANGUAGE: eng

NlmUniqueID: 1275002

Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. Keywords Mesh Terms:

KEYWORDS: Immunologic Deficiency Syndromes

MESH TERMS: immunology

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Grant and Affiliation Information for Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee.

AFFILIATION: Division of Immunology, Children's Hospital, Boston, MA 02115, USA. faif.geha@childrens.harvard.edu

Country: United States

AGENCY: United States NIAID

GRANT: AI-35714

ACRONYM: AI

MEDLINETA: J Allergy Clin Immunol

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