Primary biliary cirrhosis in female subjects with sicca-associated antibodies.

Primary biliary cirrhosis in female subjects with sicca-associated antibodies. Research Abstract Details 

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Primary biliary cirrhosis in female subjects with sicca-associated antibodies. Abstract Text:

Kunio Takada,Kimihiro Suzuki,Mitsuyo Matsumoto,Makoto Okada,Takashi Nakanishi,Hideyuki Horikoshi,Tomoaki Higuchi,Fumitaka Ohsuzu,Kunio Takada,Kimihiro Suzuki,Mitsuyo Matsumoto,Makoto Okada,Takashi Nakanishi,Hideyuki Horikoshi,Tomoaki Higuchi,Fumitaka Ohsuzu,Kunio Takada,Kimihiro Suzuki,Mitsuyo Matsumoto,Makoto Okada,Takashi Nakanishi,Hideyuki Horikoshi,Tomoaki Higuchi,Fumitaka Ohsuzu,

The aim of this study is to clarify the time course of primary biliary cirrhosis (PBC) in subjects possessing anticentromere antibodies (ACA), anti-Ro, and/or anti-La antibodies, and who used alkaline phosphatase (ALP) as a serological marker for PBC. Female subjects (n = 165), who had at least one of ACA, anti-Ro, and/or anti-La, were enrolled in this study. Groups A (ACA alone, n = 44), B (anti-Ro alone, n = 54), E (anti-Ro and anti-La, n = 52), and DFG (ACA with anti-Ro and/or anti-La, n = 14) were analyzed. Healthy females (n = 65) were used as a control. The frequencies of the PBC in groups A (13.6%) and DFG (14.3%) were higher than those in groups B (1.9%) and E (0.0%). The ALP levels increased with age in groups A and DFG and slightly increased with age in groups B and C, and the control group. After correcting for age by analysis of covariance, a comparison of ALP levels among the groups not having anti-M(2) was as follows: group A falling dots group DFG > group B falling dots group E falling dots the control group. The subjects with ACA might thus have PBC more frequently than either those with anti-Ro and/or anti-La, or the control subjects.

Primary biliary cirrhosis in female subjects with sicca-associated antibodies. Publishing Authors By Initials

K Takada,K Suzuki,M Matsumoto,M Okada,T Nakanishi,H Horikoshi,T Higuchi,F Ohsuzu,K Takada,K Suzuki,M Matsumoto,M Okada,T Nakanishi,H Horikoshi,T Higuchi,F Ohsuzu,K Takada,K Suzuki,M Matsumoto,M Okada,T Nakanishi,H Horikoshi,T Higuchi,F Ohsuzu,

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Primary biliary cirrhosis in female subjects with sicca-associated antibodies. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Modern rheumatology / the Japan Rheumatism Associa

VOLUME: 17

Page Numbers: 486-91

Journal Abbreviation: Mod Rheumatol

ISSN: 1439-7595

DAY: 20

MONTH: 12

YEAR: 2007

Primary biliary cirrhosis in female subjects with sicca-associated antibodies. Information

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LANGUAGE: eng

NlmUniqueID: 100959226

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Grant and Affiliation Information for Primary biliary cirrhosis in female subjects with sicca-associated antibodies.

AFFILIATION: Department of Internal Medicine, Division of Rheumatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan, dr20021@ndmc.ac.jp.

Country: Japan

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MEDLINETA: Mod Rheumatol

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