Primary biliary cirrhosis: critical evaluation and treatment policies.

Primary biliary cirrhosis: critical evaluation and treatment policies. Research Abstract Details 

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Primary biliary cirrhosis: critical evaluation and treatment policies. Abstract Text:

S Sherlock,

Primary biliary cirrhosis is a disease where small intra-hepatic bile ducts are destroyed as a result of an immunological reaction, presumably by cytotoxic T-lymphocytes on biliary epithelium. Analogies can be made to the graft-versus-host reaction. Hepatic copper retention is secondary to cholestasis. A circulating mitochondrial antibody is virtually constant. A mitochondrial antibody, specific for primary biliary cirrhosis, has been identified. Liver biopsy appearances have been staged but there are difficulties because of the varying rte of evolution in different parts of the liver, the focal nature of the changes and the lack of correlation with the clinical picture. Other diagnostic criteria include female sex, raised serum alkaline phosphatase values and various associated diseases. Many patients are now diagnosed when presymptomatic and such patients, particularly with granulomas in the liver, may have a normal life expectancy. General therapeutic measures include control of pruritus and prevention of fat soluble vitamin and calcium deficiencies. There is no specific treatment but D-penicillamine is useful in the later stages and prolongs survival. The prognosis in those with progressive jaundice is very poor.

Primary biliary cirrhosis: critical evaluation and treatment policies. Publishing Authors By Initials

S Sherlock,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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Primary biliary cirrhosis: critical evaluation and treatment policies. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 77

Page Numbers: 63-74

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1982

Primary biliary cirrhosis: critical evaluation and treatment policies. Information

Number of References: 70

LANGUAGE: eng

NlmUniqueID: 437034

Primary biliary cirrhosis: critical evaluation and treatment policies. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Primary biliary cirrhosis: critical evaluation and treatment policies. Information

Substance Name: Copper

Registry Number: 7440-50-8

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Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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