Primary acquired melanosis of the conjunctiva: experience with 311 eyes.

Primary acquired melanosis of the conjunctiva: experience with 311 eyes. Research Abstract Details 

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Primary acquired melanosis of the conjunctiva: experience with 311 eyes. Abstract Text:

PURPOSE: To evaluate clinical features and risks for transformation of conjunctival primary acquired melanosis (PAM) into melanoma. METHODS: Retrospective chart review and Kaplan-Meier estimates of times to PAM enlargement, recurrence, and transformation into melanoma. MAIN OUTCOME MEASURES: PAM enlargement, recurrence, and transformation into melanoma. RESULTS: The mean patient age at diagnosis of PAM was 56 years; 62% were female and 96% Caucasian. The conjunctival quadrant(s) affected by PAM and its extent in clock hours were recorded. Initial management included observation in 62%, biopsy combined with cryotherapy in 34%, and other methods in 4%. Of PAM that was observed, Kaplan-Meier estimates at 10 years revealed PAM enlargement in 35% and transformation into melanoma in 12%. Of those that underwent incisional or excisional biopsy, 10-year estimates of PAM recurrence and transformation into melanoma were 58% and 11%, respectively. Progression to melanoma occurred in 0% of PAM without atypia, 0% of PAM with mild atypia, and 13% of PAM with severe atypia. Multivariable analysis revealed that the most significant factor for both PAM recurrence and progression to melanoma was extent of PAM in clock hours. CONCLUSION: PAM without atypia or with mild atypia shows 0% progression into melanoma, whereas PAM with severe atypia shows progression into melanoma in 13%. The greater the extent of PAM in clock hours, the greater the risk for transformation into melanoma.

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Primary acquired melanosis of the conjunctiva: experience with 311 eyes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Transactions of the American Ophthalmological Soci

VOLUME: 105

Page Numbers: 61-71; discussion 71-2

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ISSN: 1545-6110

DAY: 22

MONTH: 04

YEAR: 2007

Primary acquired melanosis of the conjunctiva: experience with 311 eyes. Information

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LANGUAGE: eng

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AFFILIATION: Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Country: United States

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MEDLINETA: Trans Am Ophthalmol Soc

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