Preventive effects of perioperative parecoxib on post-discectomy pain.

Preventive effects of perioperative parecoxib on post-discectomy pain. Research Abstract Details 

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Preventive effects of perioperative parecoxib on post-discectomy pain. Abstract Text:

G Riest,J Peters,M Weiss,S Dreyer,P D Klassen,B Stegen,A Bello,M Eikermann,G Riest,J Peters,M Weiss,S Dreyer,P D Klassen,B Stegen,A Bello,M Eikermann,G Riest,J Peters,M Weiss,S Dreyer,P D Klassen,B Stegen,A Bello,M Eikermann,

BACKGROUND: /st> Cyclooxygenase inhibitor treatment is viewed increasingly critical because of safety considerations, and there are several open questions on their optimal use. METHODS: /st> In a randomized placebo-controlled study in 320 patients undergoing discectomy, we administered parecoxib 40 mg either perioperatively (before operation and after operation), after operation (first dose given in the evening after surgery), or before operation (single parecoxib dose given 45 min before surgery). We measured the main outcome variables: average pain score, morphine consumption, and opioid-related symptom distress at 25, 49, and 73 h after surgery. RESULTS: /st> Perioperative parecoxib significantly (i) improved the pain score compared with both placebo and postoperative parecoxib, (ii) decreased morphine consumption, and (iii) reduced the opioid-related symptom distress score. Neither a single preoperative dose nor postoperative parecoxib (first dose given in the evening after surgery) significantly improved morphine's analgesic effectiveness. CONCLUSIONS: /st> Perioperative parecoxib compared with postoperative parecoxib improves post-discectomy pain and results in a reduction in adverse effects associated with opioid therapy. Postoperative parecoxib, or a single pre-incisional parecoxib dose, does not significantly improve post-discectomy pain or opioid side-effects up to 3 days after surgery.

Preventive effects of perioperative parecoxib on post-discectomy pain. Publishing Authors By Initials

G Riest,J Peters,M Weiss,S Dreyer,PD Klassen,B Stegen,A Bello,M Eikermann,G Riest,J Peters,M Weiss,S Dreyer,PD Klassen,B Stegen,A Bello,M Eikermann,G Riest,J Peters,M Weiss,S Dreyer,PD Klassen,B Stegen,A Bello,M Eikermann,

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Preventive effects of perioperative parecoxib on post-discectomy pain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of anaesthesia

VOLUME: 100

Page Numbers: 256-62

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ISSN: 1471-6771

DAY: 13

MONTH: 12

YEAR: 2007

Preventive effects of perioperative parecoxib on post-discectomy pain. Information

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LANGUAGE: eng

NlmUniqueID: 372541

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AFFILIATION: Klinik für Anästhesiologie und Intensivmedizin.

Country: England

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MEDLINETA: Br J Anaesth

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