The effects of plant and yeast cerebrosides on melanin formation were examined in B16 mouse melanoma cells. Addition of yeast cerebroside significantly reduced melanin content to the same level as that of arbutin in control cells, although there was no suppression by plant cerebrosides and bovine brain cerebroside up-regulated melanin formation. None of the bovine brain cerebrosides examined had any effect on tyrosinase activity, but yeast cerebroside reduced the contents of tyrosinase. The results of the present study clearly showed that melanin formation is regulated by several different cerebrosides via tyrosinase. In addition, the findings presented here suggest that cerebrosides containing a 9-methyl type sphingoid base, such as yeast cerebroside, may be useful as skincare products for suppressing melanin formation.
Prevention of melanin formation by yeast cerebroside in B16 mouse melanoma cells. Publishing Authors By Initials
Prevention of melanin formation by yeast cerebroside in B16 mouse melanoma cells. Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: Journal of oleo science
VOLUME: 56
Page Numbers: 645-8
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ISSN: 1347-3352
DAY: 9
MONTH: 11
YEAR: 2007
Prevention of melanin formation by yeast cerebroside in B16 mouse melanoma cells. Information
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LANGUAGE: eng
NlmUniqueID: 101175339
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Grant and Affiliation Information for Prevention of melanin formation by yeast cerebroside in B16 mouse melanoma cells.
AFFILIATION: Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan. kinosita@obihiro.ac.jp
Country: Japan
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MEDLINETA: J Oleo Sci
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