Prevention of malignant hypertension in salt loaded "S" Dahl rats with the calcium antagonist nifedipine.

Prevention of malignant hypertension in salt loaded "S" Dahl rats with the calcium antagonist nifedipine. Research Abstract Details 

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Prevention of malignant hypertension in salt loaded "S" Dahl rats with the calcium antagonist nifedipine. Abstract Text:

S Kazda,B Garthoff,J Dycka,J Iwai,

Female "S" Dahl rats, fed an 8% NaCl diet from the 6th week of age developed malignant hypertension and heart hypertrophy in the course of 6 weeks on the salt regimen. Simultaneous treatment with nifedipine (300 ppm in diet additional to 8% NaCl) prevented the increase in blood pressure, reduced heart hypertrophy and mortality and improved the impaired renal function in "S" rats. The decrease in hematocrit in salt loaded "S" rats was prevented by nifedipine. The prophylactic effect of the calcium antagonist nifedipine is only partly due to the prevention of increase in systemic vascular resistance. In addition an improvement of failed intrarenal hemodynamics by nifedipine can be postulated. This enables the kidney of "S" rats to excrete the salt load without increasing blood pressure and plasma volume.

Prevention of malignant hypertension in salt loaded "S" Dahl rats with the calcium antagonist nifedipine. Publishing Authors By Initials

S Kazda,B Garthoff,J Dycka,J Iwai,

For similar organic chemicals: urea research abstracts see: organic chemicals: urea research

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Prevention of malignant hypertension in salt loaded "S" Dahl rats with the calcium antagonist nifedipine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 4

Page Numbers: 1231-41

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1982

Prevention of malignant hypertension in salt loaded "S" Dahl rats with the calcium antagonist nifedipine. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

Prevention of malignant hypertension in salt loaded "S" Dahl rats with the calcium antagonist nifedipine. Keywords Mesh Terms:

KEYWORDS: Urea

MESH TERMS: blood

Chemical & Substance for Abstract: Prevention of malignant hypertension in salt loaded "S" Dahl rats with the calcium antagonist nifedipine. Information

Substance Name: Sodium Chloride

Registry Number: 7647-14-5

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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