Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands.

Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands. Abstract Text:

Ana P Cotrim,Anastasia Sowers,James B Mitchell,Bruce J Baum,Ana P Cotrim,Anastasia Sowers,James B Mitchell,Bruce J Baum,Ana P Cotrim,Anastasia Sowers,James B Mitchell,Bruce J Baum,

Treatment of most head and neck cancers includes radiotherapy. Salivary glands (SGs) in the irradiation (IR) field are irreversibly damaged resulting in severe hyposalivation. We evaluated the importance of SG endothelial cells to this IR-induced injury, and whether serotype 5 adenoviral (Ad5) vector-mediated transfer of basic fibroblast growth factor (AdbFGF) or vascular endothelial growth factor (AdVEGF) complementary DNAs would afford radioprotection. Four hours after IR, microvessel density (MVD) in SGs decreased by approximately 45%. However, if mice were pre-treated with either AdVEGF or AdbFGF 48 hours before IR the loss in MVD was significantly reduced. An irrelevant vector, AdLacZ, encoding Escherichia coli beta-galactosidase, was without effect. After 8 weeks, IR reduced salivary flow by approximately 65% in untreated mice. Mice pre-treated (using 5 x 10(9) particles/gland 48 hours prior to IR) with AdLacZ exhibited a reduction in salivary flow similar to untreated mice receiving IR. However, irradiated mice pre-treated with AdbFGF or AdVEGF showed a significant improvement in their salivary flow, to approximately 70% (P < 0.01) and 80% (P < 0.01), respectively, compared to non-irradiated control mice. These results are consistent with the notion that injury to the adjacent microvasculature may play an important role in SG radiation damage. Furthermore, our results suggest that a local transient treatment directed at protecting SG endothelial cells may be beneficial for patients undergoing IR for head and neck cancer.Molecular Therapy (2007) 15 12, 2101-2106. doi:10.1038/sj.mt.6300296.

Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands. Publishing Authors By Initials

AP Cotrim,A Sowers,JB Mitchell,BJ Baum,AP Cotrim,A Sowers,JB Mitchell,BJ Baum,AP Cotrim,A Sowers,JB Mitchell,BJ Baum,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular therapy : the journal of the American So

VOLUME: 15

Page Numbers: 2101-6

Journal Abbreviation: Mol. Ther.

ISSN: 1525-0016

DAY: 28

MONTH: 08

YEAR: 2007

Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890581

Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands.

AFFILIATION: 1Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands Related Publications

• A lifetime in breast cancer research.
• Acute urinary tract infections in infants and children.
• Adjunctive self-hypnotic relaxation for outpatient medical procedures: a prospective randomized trial with women undergoing large core breast biopsy.
• Bilateral damage to the sexually dimorphic medial preoptic area/anterior hypothalamus of male ferrets causes a female-typical preference for and a hypothalamic Fos response to male body odors.
• Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins.
• Comparison of urinary odor-induced glomerular activation in the main olfactory bulb of aromatase knock-out and wild type female mice.
• Distinguishing among structural ensembles of the GB1 peptide: REMD simulations and NMR experiments.
• Galectin interactions with extracellular matrix and effects on cellular function.
• Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death.
• Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands.
• Happy anniversary.
• Insertional mutagenesis in gene therapy and stem cell biology.
• Mammalian animal models of psychosexual differentiation: when is 'translation' to the human situation possible?
• Mercury intoxication: lack of correlation between symptoms and levels.
• NMR shows hydrophobic interactions replace glycine packing in the triple helix at a natural break in the (Gly-X-Y)n repeat.
• Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam.
• O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1.
• Ontogeny of NHE8 in the rat proximal tubule.
• Physical properties, durability, and energy-dissipation function of dual-density orthotic materials used in insoles for diabetic patients.
• Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone.
• Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands.
• Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.
• Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity.
• Sequence dependence of renucleation after a Gly mutation in model collagen peptides.
• Sexually dimorphic activation of the accessory, but not the main, olfactory bulb in mice by urinary volatiles.
• Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.
• Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.
• Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets.
• [Difficulty in swallowing]
• [Effect of certain substances on limits of the explosion of hydrogen-air mixture.]