Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol.

Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol. Research Abstract Details 

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Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol. Abstract Text:

Danijel Juric,Peter Wojciechowski,Dipak K Das,Thomas Netticadan,

This study was designed to examine the effects of the antioxidant resveratrol on cardiac structure and function in pressure overload (PO)-induced cardiac hypertrophy. Male Sprague-Dawley rats were subjected to sham operation and the aortic banding procedure. A subgroup of sham control and aortic-banded rats were treated with resveratrol for 2 wk after surgery. Echocardiographic analysis of cardiac structure and function along with Western blot analysis of endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and redox factor-1 (ref-1) were performed in all groups after 4 wk of surgery. Banded rats showed significantly increased left ventricle-to-body weight ratio. Echocardiographic analysis showed that the interventricular septal wall thickness and left ventricular posterior wall thickness at systole and diastole were significantly increased in banded rats. Also, a significant increase in isovolumic relaxation time was observed in banded rats. Measured eNOS, iNOS, and ref-1 protein levels were significantly reduced in banded rats. Resveratrol treatment prevented the above changes in cardiac structure, function, and protein expression in banded rats. Aortic banding after 4 wk resulted in concentric remodeling and impaired contractile function due to PO on the heart. The 2-wk treatment with resveratrol was found to abolish PO-induced cardiac hypertrophy. Resveratrol may therefore be beneficial against PO-induced cardiac hypertrophy found in clinical settings of hypertension and aortic valve stenosis.

Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol. Publishing Authors By Initials

D Juric,P Wojciechowski,DK Das,T Netticadan,

For similar cardiovascular diseases: heart diseases: ventricular dysfunction: ventricular dysfunction, left research abstracts see: cardiovascular diseases: heart diseases: ventricular dysfunction: ventricular dysfunction, left research

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Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Heart and circulat

VOLUME: 292

Page Numbers: H2138-43

Journal Abbreviation: Am. J. Physiol. Heart Circ. Ph

ISSN: 0363-6135

DAY: 3

MONTH: May

YEAR: 2007

Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol. Information

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LANGUAGE: eng

NlmUniqueID: 100901228

Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol. Keywords Mesh Terms:

KEYWORDS: Ventricular Dysfunction, Left

MESH TERMS: ultrasonography

Chemical & Substance for Abstract: Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol. Information

Substance Name: resveratrol

Registry Number: 501-36-0

Grant and Affiliation Information for Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol.

AFFILIATION: Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 33889

ACRONYM: HL

MEDLINETA: Am J Physiol Heart Circ Physio

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