Preventing Renal Dysfunction in Patients with Hypertension : Clinical Implications from the Early AASK Trial Results.

Preventing Renal Dysfunction in Patients with Hypertension : Clinical Implications from the Early AASK Trial Results. Research Abstract Details 

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Preventing Renal Dysfunction in Patients with Hypertension : Clinical Implications from the Early AASK Trial Results. Abstract Text:

Janice P Lea,Denyse T Brown,Michael Lipkowitz,John Middleton,Keith Norris, ,

Strategies to delay progression of established renal disease have primarily been directed at examining the class of antihypertensive therapy and/or the level of blood pressure control. In diabetic renal disease many trials have noted a protective role of ACE inhibitor-based therapy over non-ACE inhibitor-based therapy. This paper reviews recent clinical trials evaluating hypertension-related kidney disease including the interim results of the African-American Study of Kidney Diseases and Hypertension (AASK) Study, to date the largest prospective study of African-American patients with kidney disease due to hypertension. This trial reports a renoprotective effect of ACE inhibitor-based therapy over calcium-channel antagonist- based therapy. The renoprotective effect of ACE inhibitor-based therapy may, in part, be due to their antiproteinuric effect independent of blood pressure lowering.

Preventing Renal Dysfunction in Patients with Hypertension : Clinical Implications from the Early AASK Trial Results. Publishing Authors By Initials

JP Lea,DT Brown,M Lipkowitz,J Middleton,K Norris, ,

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Preventing Renal Dysfunction in Patients with Hypertension : Clinical Implications from the Early AASK Trial Results. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of cardiovascular drugs : drugs,

VOLUME: 3

Page Numbers: 193-200

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ISSN: 1175-3277

DAY: 19

MONTH: 01

YEAR: 2003

Preventing Renal Dysfunction in Patients with Hypertension : Clinical Implications from the Early AASK Trial Results. Information

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LANGUAGE: eng

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AFFILIATION: Emory University School of Medicine, Atlanta, Georgia, USA.

Country: New Zealand

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MEDLINETA: Am J Cardiovasc Drugs

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