Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators.

Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. Research Abstract Details 

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Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. Abstract Text:

Sergey Yaklichkin,Alexander Vekker,Steven Stayrook,Mitchell Lewis,Daniel S Kessler,

BACKGROUND: The Fox gene family comprises a large and functionally diverse group of forkhead-related transcriptional regulators, many of which are essential for metazoan embryogenesis and physiology. Defining conserved functional domains that mediate the transcriptional activity of Fox proteins will contribute to a comprehensive understanding of the biological function of Fox family genes. RESULTS: Systematic analysis of 458 protein sequences of the metazoan Fox family was performed to identify the presence of the engrailed homology-1 motif (eh1), a motif known to mediate physical interaction with transcriptional corepressors of the TLE/Groucho family. Greater than 50% of Fox proteins contain sequences with high similarity to the eh1 motif, including ten of the nineteen Fox subclasses (A, B, C, D, E, G, H, I, L, and Q) and Fox proteins of early divergent species such as marine sponge. The eh1 motif is not detected in Fox proteins of the F, J, K, M, N, O, P, R and S subclasses, or in yeast Fox proteins. The eh1-like motifs are positioned C-terminal to the winged helix DNA-binding domain in all subclasses except for FoxG proteins, which have an N-terminal motif. Two similar eh1-like motifs are found in the zebrafish FoxQ1 and in FoxG proteins of sea urchin and amphioxus. The identification of eh1-like motifs by manual sequence alignment was validated by statistical analyses of the Swiss protein database, confirming a high frequency of occurrence of eh1-like sequences in Fox family proteins. Structural predictions suggest that the majority of identified eh1-like motifs are short alpha-helices, and wheel modeling revealed an amphipathicity that supports this secondary structure prediction. CONCLUSION: A search for eh1 Groucho interaction motifs in the Fox gene family has identified eh1-like sequences in greater than 50% of Fox proteins. The results predict a physical and functional interaction of TLE/Groucho corepressors with many members of the Fox family of transcriptional regulators. Given the functional importance of the eh1 motif in transcriptional regulation, our annotation of this motif in the Fox gene family will facilitate further study of the diverse transcriptional and regulatory roles of Fox family proteins.

Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. Publishing Authors By Initials

S Yaklichkin,A Vekker,S Stayrook,M Lewis,DS Kessler,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: BMC genomics

VOLUME: 8

Page Numbers: 201

Journal Abbreviation: BMC Genomics

ISSN: 1471-2164

DAY: 28

MONTH: 06

YEAR: 2007

Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100965258

Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. Information

Substance Name: engrailed homeobox proteins

Registry Number: 0

Grant and Affiliation Information for Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators.

AFFILIATION: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1110 Biomedical Research Building II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA. yaklichk@mail.med.upenn.edu

Country: England

AGENCY: United States NIGMS

GRANT: GM64768

ACRONYM: GM

MEDLINETA: BMC Genomics

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