Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children.

Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Research Abstract Details 

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Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Abstract Text:

Melissa A Brotman,Mariana Schmajuk,Brendan A Rich,Daniel P Dickstein,Amanda E Guyer,E Jane Costello,Helen L Egger,Adrian Angold,Daniel S Pine,Ellen Leibenluft,

BACKGROUND: Controversy concerning the diagnosis of pediatric bipolar disorder (BD) has focused attention on children with chronic irritability and hyperarousal. This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample. METHODS: Data were drawn from the Great Smoky Mountains Study, a longitudinal epidemiological study. Items from the Child and Adolescent Psychiatric Assessment were used to generate SMD criteria. RESULTS: Among 1420 children, the lifetime prevalence of SMD in children ages 9-19 was 3.3%. Most (67.7%) SMD youth had an Axis I diagnosis, most commonly attention-deficit/hyperactivity disorder (26.9%), conduct disorder (25.9%), and/or oppositional defiant disorder (24.5%). In young adulthood (mean age 18.3 +/- 2.1 years), youth who met criteria for SMD in the first wave (mean age 10.6 +/- 1.4 years) were significantly more likely to be diagnosed with a depressive disorder (odds ratio 7.2, confidence interval 1.3-38.8, p = .02) than youth who never met criteria for SMD. CONCLUSIONS: Severe mood dysregulation is relatively common in childhood and predicts risk for early adulthood depressive disorders. Research should continue to explore the course of illness in children with SMD.

Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Publishing Authors By Initials

MA Brotman,M Schmajuk,BA Rich,DP Dickstein,AE Guyer,EJ Costello,HL Egger,A Angold,DS Pine,E Leibenluft,

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Biological psychiatry

VOLUME: 60

Page Numbers: 991-7

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 1

MONTH: Nov

YEAR: 2006

Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: statistics & numerical data

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Grant and Affiliation Information for Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children.

AFFILIATION: Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. brotmanm@mail.nih.gov

Country: United States

AGENCY: United States NIMH

GRANT: MH01167

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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