Prevalence and patterns of soft tissue metastasis: detection with true whole-body F-18 FDG PET/CT.

Prevalence and patterns of soft tissue metastasis: detection with true whole-body F-18 FDG PET/CT. Research Abstract Details 

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Prevalence and patterns of soft tissue metastasis: detection with true whole-body F-18 FDG PET/CT. Abstract Text:

Nghi C Nguyen,Bassem T Chaar,Medhat M Osman,

BACKGROUND: The aim of this retrospective study was to report the prevalence and patterns of soft tissue (ST) metastasis detected with true whole-body (TWB) F-18 FDG PET/CT acquired from the top of the skull through the bottom of the feet and to compare such findings to that of the typically acquired skull-base to upper-thigh, thus limited whole-body (LWB) field of view (FOV). METHODS: TWB FDG-PET/CT scans were performed in 500 consecutive cancer patients. Suspected ST metastasis was verified by correlation with surgical pathology, other imaging modalities, or clinical follow-up. RESULTS: Nine out of 500 patients (1.8 %) had ST metastasis with a prevalence of 4/41 (9.8%) for melanoma, 2/60 (3.3%) for lung carcinoma, 2/88 (2.3%) for lymphoma and 1/13 (77%) for esophageal cancer. Those nine patients had a total of 41 ST lesions: 22 lesions within and 19 outside of LWB FOV. Of those 41 lesions, 19 (46%) were subcutaneous and 22 (54%) were muscular lesions. The presence of ST metastasis neither changed the staging nor the treatment in any of these patients. However, the ST lesions provided a biopsy site in 4 of the 9 patients (44%). Seven out of nine studied patients died of their disease within 1-22 months after ST metastasis was diagnosed. CONCLUSION: The detection of ST metastasis may have prognostic implications, provide more accessible biopsy sites and help avoid invasive procedures. A LWB scanning may underestimate the true extent of ST metastasis since a significant percentage of ST metastasis (46%) occurred outside the typical LWB FOV.

Prevalence and patterns of soft tissue metastasis: detection with true whole-body F-18 FDG PET/CT. Publishing Authors By Initials

NC Nguyen,BT Chaar,MM Osman,

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Prevalence and patterns of soft tissue metastasis: detection with true whole-body F-18 FDG PET/CT. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: BMC medical imaging

VOLUME: 7

Page Numbers: 8

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ISSN: 1471-2342

DAY: 12

MONTH: 12

YEAR: 2007

Prevalence and patterns of soft tissue metastasis: detection with true whole-body F-18 FDG PET/CT. Information

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LANGUAGE: eng

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AFFILIATION: Division of Nuclear Medicine, Department of Radiology, Saint Louis University Hospital, St, Louis, USA. Nghihoaben@yahoo.com

Country: England

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MEDLINETA: BMC Med Imaging

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