Prevalence and infection load dynamics of Rickettsia felis in actively feeding cat fleas.

Prevalence and infection load dynamics of Rickettsia felis in actively feeding cat fleas. Research Abstract Details 

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Prevalence and infection load dynamics of Rickettsia felis in actively feeding cat fleas. Abstract Text:

BACKGROUND: Rickettsia felis is a flea-associated rickettsial pathogen recurrently identified in both colonized and wild-caught cat fleas, Ctenocephalides felis. We hypothesized that within colonized fleas, the intimate relationship between R. felis and C. felis allows for the coordination of rickettsial replication and metabolically active periods during flea bloodmeal acquisition and oogenesis. METHODOLOGY/PRINCIPAL FINDINGS: A quantitative real-time PCR assay was developed to quantify R. felis in actively feeding R. felis-infected fleas. In three separate trials, fleas were allowed to feed on cats, and a mean of 3.9x10(6) R. felis 17-kDa gene copies was detected for each flea. A distinct R. felis infection pattern was not observed in fleas during nine consecutive days of bloodfeeding. However, an inverse correlation between the prevalence of R. felis-infection, which ranged from 96% in Trial 1 to 35% in Trial 3, and the R. felis-infection load in individual fleas was identified. Expression of R. felis-infection load as a ratio of R. felis/C. felis genes confirmed that fleas in Trial 3 had significantly greater rickettsial loads than those in Trial 1. CONCLUSION/SIGNIFICANCE: Examining rickettsial infection dynamics in the flea vector will further elucidate the intimate relationship between R. felis and C. felis, and facilitate a more accurate understanding of the ecology and epidemiology of R. felis transmission in nature.

Prevalence and infection load dynamics of Rickettsia felis in actively feeding cat fleas. Publishing Authors By Initials

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Prevalence and infection load dynamics of Rickettsia felis in actively feeding cat fleas. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: PLoS ONE

VOLUME: 3

Page Numbers: e2805

Journal Abbreviation: PLoS ONE

ISSN: 1932-6203

DAY: 30

MONTH: 07

YEAR: 2008

Prevalence and infection load dynamics of Rickettsia felis in actively feeding cat fleas. Information

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LANGUAGE: eng

NlmUniqueID: 101285081

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Grant and Affiliation Information for Prevalence and infection load dynamics of Rickettsia felis in actively feeding cat fleas.

AFFILIATION: Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America.

Country: United States

AGENCY: United States NCRR

GRANT: T35 RR017504-01

ACRONYM: RR

MEDLINETA: PLoS ONE

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