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Preparation of three-dimensional fibroin/collagen scaffolds in various pH conditions.

Preparation of three-dimensional fibroin/collagen scaffolds in various pH conditions. Research Abstract Details 

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  • Preparation of three-dimensional fibroin/collagen scaffolds in various pH conditions. Abstract Text:

    qiang luQiang Lu,qingling fengQingling Feng,kun huKun Hu,fuzhai cuiFuzhai Cui,

    Three dimensional (3-D) fibroin/collagen scaffolds are the novel fibroin based scaffolds derived from aqueous solution. In this article, we investigated the effect of pH on the formation of fibroin/collagen scaffolds. In the range of pH from 4 to 8.5, the fibroin/collagen scaffolds with good porous structures can be prepared using freeze-drying method, which would facilitate the adding of other biopolymers. The structures of different fibroin-based scaffolds were investigated with FTIR and DSC, which indicated that the interaction of fibroin and collagen affected the methanol-induced transformation of fibroin from random-coil to beta-sheet conformation. The mechanical properties were also studied. The results mean that all the fibroin-based scaffolds prepared in various pH values had better mechanical properties than other reported fibroin scaffolds. Since the fibroin/collagen scaffolds can be prepared in the range of pH from 4 to 8.5, it is very easy to prepare different multifunctional scaffolds such as fibroin/collagen/chitosan scaffolds and fibroin/collagen/heparin scaffolds in acidic or neutral conditions. These new fibroin-based blend materials extend the range of biomaterial properties that can promote the use in biomedical applications such as drug release and tissue engineering.

    Preparation of three-dimensional fibroin/collagen scaffolds in various pH conditions. Publishing Authors By Initials

    q luQ Lu,q fengQ Feng,k huK Hu,f cuiF Cui,

    For similar abstracts research abstracts see: abstracts research

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    Preparation of three-dimensional fibroin/collagen scaffolds in various pH conditions. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Journal of materials science. Materials in medicin

    VOLUME: 19

    Page Numbers: 629-34

    Journal Abbreviation:

    ISSN: 0957-4530

    DAY: 10

    MONTH: 07

    YEAR: 2007

    Preparation of three-dimensional fibroin/collagen scaffolds in various pH conditions. Information

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    LANGUAGE: eng

    NlmUniqueID: 9013087

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    Grant and Affiliation Information for Preparation of three-dimensional fibroin/collagen scaffolds in various pH conditions.

    AFFILIATION: Laboratory of Advanced Materials, Department of Material Science and Engineering, Tsinghua University, Beijing, 100084, P.R. China.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: J Mater Sci Mater Med

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