Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus.

Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus. Research Abstract Details 

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Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus. Abstract Text:

B Zhu,H Iwata,D Kong,Y Yu,K Kato,Y Ikada,

A new DNA-immobilized immunoadsorbent was prepared to remove the pathogenic anti-DNA antibody from the serum of systemic lupus erythematosus (SLE) patients. A non-woven poly(ethylene terephthalate) (PET) fabric made of 3.5-microm diameter fibers was used as the support of the immunoadsorbent. A cationic monomer, N,N-dimethylaminoethyl methacrylate (DAM), was graft polymerized onto the PET fiber surface by UV irradiation or with a chemical initiator. Polyion complexation between the cationic groups of the graft chains and DNA molecules was employed to immobilize DNA onto the fiber surface. No DNA leaching was observed when the DNA-immobilized fabrics were placed in 0.9 and 2.0 wt% NaCl solution at 37 degrees C overnight. In vitro evaluation of this DNA-immobilized immunoadsorbent demonstrated that this adsorbent could selectively adsorb anti-DNA antibody from the serum of SLE patients.

Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus. Publishing Authors By Initials

B Zhu,H Iwata,D Kong,Y Yu,K Kato,Y Ikada,

For similar environment and public health: environment: meteorological factors: atmosphere: weather: sunlight: ultraviolet rays research abstracts see: environment and public health: environment: meteorological factors: atmosphere: weather: sunlight: ultraviolet rays research

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Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 10

Page Numbers: 341-50

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 1999

Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus. Keywords Mesh Terms:

KEYWORDS: Ultraviolet Rays

MESH TERMS: radiation effects

Chemical & Substance for Abstract: Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus.

AFFILIATION: Institute for Frontier Medical Sciences, Kyoto University, Japan.

Country: NETHERLANDS

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MEDLINETA: J Biomater Sci Polym Ed

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