Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics.

Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics. Research Abstract Details 

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Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics. Abstract Text:

Craig A Hutton,Paul A Bartlett,

Several functionalized diazabicyclo[4.3.0]nonenes and other heterocycles have been prepared as potential peptidomimetic scaffolds. A novel and efficient method has been developed for the preparation of N-substituted gamma-lactams 13. Preparation of amidine-containing 1,5-diazabicyclo[4.3.0]nonenes 43 and 44 has been achieved through Hg-mediated cyclization of the precursor N-aminopropyl-gamma-thiolactams and subsequent functional group manipulation. Bicycle 43 represents a novel scaffold for potential peptide turn mimetics, whereas 44 could potentially be employed as an alpha-helix template attached to the C-terminus of peptides. These compounds are novel additions to the current range of small-molecule constrained peptidomimetics.

Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics. Publishing Authors By Initials

CA Hutton,PA Bartlett,

For similar peptides research abstracts see: peptides research

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Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of organic chemistry

VOLUME: 72

Page Numbers: 6865-72

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 8

MONTH: 08

YEAR: 2007

Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985193

Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics. Keywords Mesh Terms:

KEYWORDS: Peptides

MESH TERMS: chemistry

Chemical & Substance for Abstract: Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics. Information

Substance Name: 1,5-diazabicyclo(4.3.0)non-5-ene

Registry Number: 3001-72-7

Grant and Affiliation Information for Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics.

AFFILIATION: School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia. chutton@unimelb.edu.au

Country: United States

AGENCY: United States NIGMS

GRANT: GM-28965

ACRONYM: GM

MEDLINETA: J Org Chem

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