Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery.

Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery. Research Abstract Details 

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Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery. Abstract Text:

Huiqun Yu,Jun Lu,Chaobo Xiao,Huiqun Yu,Jun Lu,Chaobo Xiao,

In this paper, a novel composite hydrogel was prepared by the use of dialdehyde konjac glucomannan (DAK) as macromolecular cross-linking agent for chitosan (CS). This biocompatible material cross-links and gels in minutes. The structure and morphology were characterized by various analyses. The results indicate that the hydrogels formed through the Schiff-base reaction between the amino groups of CS chains and the aldehyde groups of DAK. The cross-link density (rho(x)) increases with the enhancement of DAK content in hydrogels, while equilibrium swelling ratio (SR) and the average molecular weight between cross-links (Mc) value decrease. Drug release was evaluated by varying the pH of the release medium, reversed dependence of release rate on the equilibrium SR of hydrogel indicated that drug release may be impeded by the association of drug with the polymer. Importantly, this process offers an entirely new window of materials preparation when compared with the traditional preparation of CS-based hydrogels with small molecules cross-linking agent.

Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery. Publishing Authors By Initials

H Yu,J Lu,C Xiao,H Yu,J Lu,C Xiao,

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Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Macromolecular bioscience

VOLUME: 7

Page Numbers: 1100-11

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ISSN: 1616-5187

DAY: 11

MONTH: Sep

YEAR: 2007

Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery.

AFFILIATION: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China.

Country: Germany

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MEDLINETA: Macromol Biosci

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