Preparation and characterization of nano-hydroxyapatite/chitosan/konjac glucomannan composite.

Preparation and characterization of nano-hydroxyapatite/chitosan/konjac glucomannan composite. Research Abstract Details 

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Preparation and characterization of nano-hydroxyapatite/chitosan/konjac glucomannan composite. Abstract Text:

Gang Zhou,Yubao Li,Li Zhang,Yi Zuo,John A Jansen,Gang Zhou,Yubao Li,Li Zhang,Yi Zuo,John A Jansen,

Nano-hydroxyapatite (n-HA)/chitosan (CS)/konjac glucomannan (KGM) composite was prepared by coprecipitation method and investigated by thermal gravitivity/differentiate thermal analysis, Fourier transform infrared spectroscopy, X-ray diffraction, inductively coupled plasma emission spectroscopy, scanning electron microscopy, and energy dispersive X-ray analyzer. The analyses showed that the three phases of n-HA, CS, and KGM combined closely to each other. Further, in vitro tests were conducted to investigate the degradation and bioactivity of the composite. During immersion in simulated body fluid (SBF), pores appeared and a new substance containing Ca and P formed on the surface of the composite. Also, the concentration of Ca and P in SBF changed and weight loss of the composite was observed during time. The composite revealed a high degradation in SBF. Evidently, the new composite has a potential to be used as a carrier of implantable drug delivery system. The biodegradation rate and route could be different from CS and KGM, which will provide an opportunity to control the degradation rate or drug releasing rate by simply adjusting the ratio of CS and KGM. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007.

Preparation and characterization of nano-hydroxyapatite/chitosan/konjac glucomannan composite. Publishing Authors By Initials

G Zhou,Y Li,L Zhang,Y Zuo,JA Jansen,G Zhou,Y Li,L Zhang,Y Zuo,JA Jansen,

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Preparation and characterization of nano-hydroxyapatite/chitosan/konjac glucomannan composite. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedical materials research. Part A

VOLUME: 83

Page Numbers: 931-9

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ISSN: 1549-3296

DAY: 15

MONTH: Dec

YEAR: 2007

Preparation and characterization of nano-hydroxyapatite/chitosan/konjac glucomannan composite. Information

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LANGUAGE: eng

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AFFILIATION: Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China.

Country: United States

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MEDLINETA: J Biomed Mater Res A

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