Preoperative serum vascular endothelial growth factor-C (VEGF-C) levels predict recurrence in patients with esophageal cancer.

Preoperative serum vascular endothelial growth factor-C (VEGF-C) levels predict recurrence in patients with esophageal cancer. Research Abstract Details 

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Preoperative serum vascular endothelial growth factor-C (VEGF-C) levels predict recurrence in patients with esophageal cancer. Abstract Text:

Hitoshi Kimura,Hiroyuki Kato,Naritaka Tanaka,Takanori Inose,Ahmad Faried,Makoto Sohda,Masanobu Nakajima,Yasuyuki Fukai,Tatsuya Miyazaki,Norihiro Masuda,Ryokuhei Manda,Minoru Fukuchi,Hitoshi Ojima,Katsuhiko Tsukada,Hiroyuki Kuwano,

BACKGROUND: Circulating vascular endothelial growth factor-C (VEGF-C) levels were measured in patients with esophageal cancer to assess the value of VEGF-C as a biomarker for predicting tumor recurrence. PATIENTS AND METHODS: Preoperative serum samples were acquired from 80 patients and healthy volunteers who served as normal controls. VEGF-C levels were assessed using enzyme-linked immunosorbent assay (ELISA). RESULTS: The preoperative serum VEGF-C level in patients with esophageal cancer was significantly higher than in healthy volunteers. Furthermore, patients with recurrence had significantly higher preoperative serum VEGF-C levels than patients without recurrence, and a high preoperative serum VEGF-C level was found to be an independent risk factor for recurrence, in addition to lymph node metastasis. CONCLUSION: Preoperative VEGF-C levels may reflect malignancy, such as lymph node metastasis, and predict recurrence in patients with esophageal cancer. Therefore, the preoperative VEGF-C level may be a useful biomarker for choice of multimodality therapy.

Preoperative serum vascular endothelial growth factor-C (VEGF-C) levels predict recurrence in patients with esophageal cancer. Publishing Authors By Initials

H Kimura,H Kato,N Tanaka,T Inose,A Faried,M Sohda,M Nakajima,Y Fukai,T Miyazaki,N Masuda,R Manda,M Fukuchi,H Ojima,K Tsukada,H Kuwano,

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Preoperative serum vascular endothelial growth factor-C (VEGF-C) levels predict recurrence in patients with esophageal cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Anticancer research

VOLUME: 28

Page Numbers: 165-9

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ISSN: 0250-7005

DAY: 3

MONTH: 04

YEAR: 2008

Preoperative serum vascular endothelial growth factor-C (VEGF-C) levels predict recurrence in patients with esophageal cancer. Information

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LANGUAGE: eng

NlmUniqueID: 8102988

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Grant and Affiliation Information for Preoperative serum vascular endothelial growth factor-C (VEGF-C) levels predict recurrence in patients with esophageal cancer.

AFFILIATION: Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, 371-8511, Japan. hkimura@med.gunma-u.ac.jp

Country: Greece

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MEDLINETA: Anticancer Res

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