Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype.

Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Research Abstract Details 

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Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Abstract Text:

Rosalind J Neuman,Elizabeth Lobos,Wendy Reich,Cynthia A Henderson,Ling-Wei Sun,Richard D Todd,

BACKGROUND: In utero exposure to smoking and alcohol are common risk factors that have been associated with attention-deficit/hyperactivity disorder (ADHD) in human beings and animal models. Furthermore, molecular studies have focused on the association between ADHD and DNA polymorphisms in dopamine pathway-related genes. We examined the joint effects of genetic and prenatal substance exposures on DSM-IV and population-defined subtypes of ADHD. METHODS: Logistic regression was used to assess the relationship between ADHD subtypes, DAT1 and DRD4 polymorphisms, and prenatal substance exposures in a birth-record sample of male and female twin pairs, aged 7-19 years. RESULTS: Interactions between prenatal exposure to smoking and variations in the DAT1 and DRD4 loci were observed in children with either the DSM-IV or population-defined ADHD combined subtypes. The odds of a diagnosis of DSM-IV combined subtype was 2.9 times greater in twins who had inherited the DAT1 440 allele and who were exposed, than in unexposed twins without the risk allele. The OR was 2.6 in the population-defined subtype. Odds ratios for the DRD4 seven-repeat allele were 3.0 (2.8) in the population-defined (DSM-IV) combined ADHD subtypes. The OR for exposed children with both alleles was 9.0 (95% confidence interval=2.0-41.5) for the population-defined combined subtypes. CONCLUSIONS: Results indicate that smoking during pregnancy is associated with specific subtypes of ADHD in genetically susceptible children.

Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Publishing Authors By Initials

RJ Neuman,E Lobos,W Reich,CA Henderson,LW Sun,RD Todd,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Journal Published:

PUBLICATION TYPE: Twin Study

Journal: Biological psychiatry

VOLUME: 61

Page Numbers: 1320-8

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 6

MONTH: 12

YEAR: 2006

Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Information

Substance Name: Dopamine

Registry Number: 51-61-6

Grant and Affiliation Information for Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype.

AFFILIATION: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. roz@gretta.wustl.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS43762

ACRONYM: NS

MEDLINETA: Biol Psychiatry

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