Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control.

Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control. Research Abstract Details 

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Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control. Abstract Text:

Susanna L Fryer,Susan F Tapert,Sarah N Mattson,Martin P Paulus,Andrea D Spadoni,Edward P Riley,

BACKGROUND: Prenatal alcohol exposure can lead to widespread cognitive impairment and behavioral dysregulation, including deficits in attention and response inhibition. This study characterized the neural substrates underlying the disinhibited behavioral profile of individuals with fetal alcohol spectrum disorders (FASD). METHODS: Children and adolescents (ages 8-18) with (n=13) and without (n=9) histories of heavy prenatal alcohol exposure underwent functional magnetic resonance imaging while performing a response inhibition (go/no-go) task. RESULTS: Despite similar task performance (mean response latency, performance accuracy, and signal detection), blood oxygen level-dependent (BOLD) response patterns differed by group. Region-of-interest analyses revealed that during portions of the behavioral task that required response inhibition, alcohol-exposed participants showed greater BOLD response across prefrontal cortical regions (including the left medial and right middle frontal gyri), while they showed less right caudate nucleus activation, compared with control participants. CONCLUSIONS: These data provide an account of response inhibition-related brain functioning in youth with FASD. Furthermore, results suggest that the frontal-striatal circuitry thought to mediate inhibitory control is sensitive to alcohol teratogenesis.

Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control. Publishing Authors By Initials

SL Fryer,SF Tapert,SN Mattson,MP Paulus,AD Spadoni,EP Riley,

For similar reaction time research abstracts see: reaction time research

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Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Alcoholism, clinical and experimental research

VOLUME: 31

Page Numbers: 1415-24

Journal Abbreviation: Alcohol. Clin. Exp. Res.

ISSN: 0145-6008

DAY: 9

MONTH: 06

YEAR: 2007

Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control. Information

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LANGUAGE: eng

NlmUniqueID: 7707242

Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control. Keywords Mesh Terms:

KEYWORDS: Reaction Time

MESH TERMS: drug effects

Chemical & Substance for Abstract: Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control.

AFFILIATION: Joint Doctoral Program in Clinical Psychology, San Diego State University, University of California, San Diego, California, USA. sfryer@ucsd.edu

Country: England

AGENCY: United States NIAAA

GRANT: U01 AA14834

ACRONYM: AA

MEDLINETA: Alcohol Clin Exp Res

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