[Preliminary study on oncogene MDM2 in acute leukemias]

[Preliminary study on oncogene MDM2 in acute leukemias] Research Abstract Details 

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[Preliminary study on oncogene MDM2 in acute leukemias] Abstract Text:

H Chao,L Wang,J Wang,Y Hao,Q Meng,K Li,B Feng,

OBJECTIVE: To explore the causes of MDM2 gene overexpression. METHODS: The amplification and overexpression of MDM2 gene in 41 acute leukemia patients and two leukemic cell lines (K051 and HL60) were studied by using Southern blot, dot hybridyzation and RT-PCR techniques. RESULTS: Overexpression of MDM2 gene was found in 51.2% (21/41) of the patients and HL60 cell line, but no amplification of the gene was found in all the patients and the two cell lines. CONCLUSION: The level of MDM2 gene expression was related to the prognoses of the patients but not to FAB subtypes of acute leukemias.

[Preliminary study on oncogene MDM2 in acute leukemias] Publishing Authors By Initials

H Chao,L Wang,J Wang,Y Hao,Q Meng,K Li,B Feng,

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[Preliminary study on oncogene MDM2 in acute leukemias] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 13-6

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 29

MONTH: Jan

YEAR: 1997

[Preliminary study on oncogene MDM2 in acute leukemias] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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