[Preliminary study on determination of specific cellular immunity of patients with hepatitis B]

[Preliminary study on determination of specific cellular immunity of patients with hepatitis B] Research Abstract Details 

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[Preliminary study on determination of specific cellular immunity of patients with hepatitis B] Abstract Text:

Jing He,Shao-jie Xin,Hong-hui Shen,Jian-yang Yang,Lei Zhu,Yan Hu,Jun Hou,Pan-yong Mao,

BACKGROUND: To evaluate an enzyme linked immunospot (ELISPOT) method for testing the specific cellular immunity of patients with hepatitis B and preliminarily investigate into the difference of cellular immunity in patients with various types of hepatitis B. METHODS: The patients with acute hepatitis B, chronic hepatitis B liver cirrhosis, healthy persons with HBV vaccine immunization, healthy persons with past HBV infection and HBV naive persons were enrolled in this study. Their peripheral blood mononuclear cells were tested by ELISPOT to determine the number of gamma-interferon secreting cells. RESULTS: The number of gamma-interferon secreting cells was significantly different between the patients with acute hepatitis B and those with chronic hepatitis B, and between the patients with acute hepatitis B and those with liver cirrhosis (P=0.0209 and P=0.0211). CONCLUSION: The specific cellular immunity in the patients with hepatitis B could be evaluated by determining the number of gamma-interferon secreting cells with the method of testing their peripheral blood mononuclear cells by ELISPOT. The specific cellular immunity was stronger in the patients with acute hepatitis B than in those with chronic hepatitis B and liver cirrhosis.

[Preliminary study on determination of specific cellular immunity of patients with hepatitis B] Publishing Authors By Initials

J He,SJ Xin,HH Shen,JY Yang,L Zhu,Y Hu,J Hou,PY Mao,

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[Preliminary study on determination of specific cellular immunity of patients with hepatitis B] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi

VOLUME: 20

Page Numbers: 33-5

Journal Abbreviation: Zhonghua Shi Yan He Lin Chuang

ISSN: 1003-9279

DAY: 27

MONTH: Mar

YEAR: 2006

[Preliminary study on determination of specific cellular immunity of patients with hepatitis B] Information

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LANGUAGE: chi

NlmUniqueID: 9602873

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Grant and Affiliation Information for [Preliminary study on determination of specific cellular immunity of patients with hepatitis B]

AFFILIATION: The No. 302 Hospital of the People's Liberation Army, Beijing 100039, China.

Country: China

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MEDLINETA: Zhonghua Shi Yan He Lin Chuang

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