[Preliminary study on alternative half body irradiation in the treatment of hematological malignancies]

[Preliminary study on alternative half body irradiation in the treatment of hematological malignancies] Research Abstract Details 

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[Preliminary study on alternative half body irradiation in the treatment of hematological malignancies] Abstract Text:

Jia-Lin Wei,Mei Wang,De-Hui Zou,Dong-Lin Yang,Rui Li,Jun Ning,Si-Zhou Feng,Ming-Zhe Han,

OBJECTIVE: To evaluate the curative effect of alternative half body irradiation (AHBI) in the treatment of hematological malignancies. METHODS: Seventeen patients with hematological malignancies in complete remission received a high-dose chemotherapy, followed by a two-step AHBI on day 14 (12 approximately 22), upper (UHBI) and lower half body irradiation (LHBI) were sequentially given with each a single dose of 6 approximately 9 Gy at an interval of 23 (7 approximately 34) days. Fourteen received autologous hematopoietic stem cell transplantation (AHSCT) during the same period were chosen as control. RESULTS: Hematopoiesis recovery was observed in all the AHBI patients. The 3-year disease free survival (DFS) rate and the AHBI-related mortality were (52.38 +/- 13.47)% and 0, respectively. The longest survival time was 1446 days with a median follow-up period of 927 (428 approximately 1446) days. The 3-year DFS for the 11 acute lymphocytic leukemia (ALL) patients was (47.73 +/- 17.55)%. By contrast, the 3-year DFS and the AHSCT-related mortality for the 14 ALL patients in the control AHSCT group were (53.88 +/- 14.08)% and 14%, respectively. There was no significant difference in 3-year DFS between AHBI and AHSCT ALL patients. CONCLUSIONS: AHBI provides a feasible approach for hematological malignancy patients.

[Preliminary study on alternative half body irradiation in the treatment of hematological malignancies] Publishing Authors By Initials

JL Wei,M Wang,DH Zou,DL Yang,R Li,J Ning,SZ Feng,MZ Han,

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[Preliminary study on alternative half body irradiation in the treatment of hematological malignancies] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 25

Page Numbers: 355-8

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 13

MONTH: Jun

YEAR: 2004

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LANGUAGE: chi

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AFFILIATION: Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Science, Tianjin 300020, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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