Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer.

Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer. Research Abstract Details 

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Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer. Abstract Text:

K L Du,R Mick,T M Busch,T C Zhu,J C Finlay,G Yu,A G Yodh,S B Malkowicz,D Smith,R Whittington,D Stripp,S M Hahn,

BACKGROUND AND OBJECTIVES: Interstitial photodynamic therapy (PDT) is an emerging modality for the treatment of solid organ disease. Our group at the University of Pennsylvania has performed extensive studies that demonstrate the feasibility of interstitial PDT for prostate cancer. Our preclinical and clinical experience is herein detailed. STUDY DESIGN/MATERIALS AND METHODS: We have treated 16 canines in preclinical studies, and 16 human subjects in a Phase I study, using motexafin lutetium-mediated PDT for recurrent prostate adenocarcinoma. Dosimetry of light fluence, drug level and oxygen distribution for these patients were performed. RESULTS: We demonstrate the safe and comprehensive treatment of the prostate using PDT. However, there is significant variability in the dose distribution and the subsequent tissue necrosis throughout the prostate. CONCLUSIONS: PDT is an attractive option for the treatment of prostate adenocarcinoma. However, the observed variation in PDT dose distribution translates into uncertain therapeutic reproducibility. Our future focus will be on the development of an integrated system that is able to both detect and compensate for dose variations in real-time, in order to deliver a consistent overall PDT dose distribution.

Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer. Publishing Authors By Initials

KL Du,R Mick,TM Busch,TC Zhu,JC Finlay,G Yu,AG Yodh,SB Malkowicz,D Smith,R Whittington,D Stripp,SM Hahn,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: blood circulation: regional blood flow research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: blood circulation: regional blood flow research

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Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Lasers in surgery and medicine

VOLUME: 38

Page Numbers: 427-34

Journal Abbreviation:

ISSN: 0196-8092

DAY: 3

MONTH: Jun

YEAR: 2006

Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8007168

Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer. Keywords Mesh Terms:

KEYWORDS: Regional Blood Flow

MESH TERMS: drug effects

Chemical & Substance for Abstract: Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer.

AFFILIATION: Department of Radiation Oncology, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Country: United States

AGENCY: United States NCI

GRANT: R21 CA88064

ACRONYM: CA

MEDLINETA: Lasers Surg Med

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