Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord.

Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord. Abstract Text:

Barclay W Bakkum,Charles N R Henderson,Se-Pyo Hong,Gregory D Cramer,

OBJECTIVE: A widely accepted theoretical model suggests that vertebral hypomobility can cause pain and abnormal spinal mechanics because of changes in sensory input from spinal and paraspinal tissues. The purpose of this pilot study was 3-fold: (1) to make a preliminary determination if chronic vertebral hypomobility at L4 through L6 in the rat would affect synaptic density and/or morphology in the superficial dorsal horn of the L2 spinal cord level, (2) to identify relevant outcome variables for future studies, and (3) to obtain preliminary data that would permit estimating an appropriate sample size for future studies. METHODS: Using an established rat model, we fixed 3 contiguous lumbar segments (L4-L6) for 8 weeks with a specially engineered vertebral fixation device. Electron micrographs were obtained from 2 animals from the experimental (fixed) group and each of 3 control groups (no surgery, surgery but no devices implanted, and devices implanted but not fixed). Synapses were randomly selected using a stereological approach and were analyzed for symmetry, curvature, type of postsynaptic profile, and perforations. The synaptic density was also estimated. RESULTS: There was increased synaptic density and percentage of positively curved synapses in the dorsal horn of experimental animals as compared with controls. Experimental animals had a lower percentage of axospinous synapses, with a concomitant increase in the percentage of synapses on dendritic shafts. CONCLUSIONS: These preliminary data suggest for the first time that chronic vertebral hypomobility at L4 through L6 in the rat affects synaptic density and morphology in the superficial dorsal horn of the L2 spinal cord level. More definitive studies are warranted, and the biologic significance of these finding should be investigated.

Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord. Publishing Authors By Initials

BW Bakkum,CN Henderson,SP Hong,GD Cramer,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

PUBMED ID PMID:

MEDLINE DATE:

Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of manipulative and physiological therapeu

VOLUME: 30

Page Numbers: 336-42

Journal Abbreviation:

ISSN: 1532-6586

DAY: 3

MONTH: Jun

YEAR: 2007

Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7807107

Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord.

AFFILIATION: Department of Basic and Health Sciences, Illinois College of Optometry, Chicago, Ill 60616, USA. bbakkum@ico.edu

Country: United States

AGENCY: United States NCRR

GRANT: C06 RR15433

ACRONYM: RR

MEDLINETA: J Manipulative Physiol Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord Related Publications

• A New Wavelet-based Technique For Analyzing Surface Mechanomyographic Signals: 1664: Board #154 May 30 2:00 PM - 3:30 PM.
• A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2.
• Auditory brainstem neural activation patterns are altered in EphA4- and ephrin-B2-deficient mice.
• Can an ancillary ligand lead to a thermodynamically stable end-on 1 : 1 Cu-O2 adduct supported by a beta-diketiminate ligand?
• Characterization of the structure and reactivity of monocopper-oxygen complexes supported by beta-diketiminate and anilido-imine ligands.
• Chromatographic alignment of LC-MS and LC-MS/MS datasets by genetic algorithm feature extraction.
• Complications of high tibial osteotomy with external fixation in adolescent Blount's disease.
• Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections.
• Dynamics of an [Fe4S4(SPh)4]2- cluster explored via IR, Raman, and nuclear resonance vibrational spectroscopy (NRVS)-analysis using 36S substitution, DFT calculations, and empirical force fields.
• EphA4 misexpression alters tonotopic projections in the auditory brainstem.
• Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence.
• High-Resolution X-ray Fluorescence and Excitation Spectroscopy of Metalloproteins.
• How nitrogenase shakes--initial information about P-cluster and FeMo-cofactor normal modes from nuclear resonance vibrational spectroscopy (NRVS).
• Investigation of multi-modal high-salt binding ion-exchange chromatography using quantitative structure-property relationship modeling.
• Methods for integrating medication compliance and persistence in pharmacoeconomic evaluations.
• Minimum length requirement of the flexible N-terminal translocation subdomain of colicin E3.
• Observation of terahertz vibrations in Pyrococcus furiosus rubredoxin via impulsive coherent vibrational spectroscopy and nuclear resonance vibrational spectroscopy--interpretation by molecular mechanics.
• Pathology of thrombotic thrombocytopenic purpura in the placenta, with emphasis on the snowman sign.
• Pooling of case specimens to create standard serum sets for screening cancer biomarkers.
• Preliminary morphological evidence that vertebral hypomobility induces synaptic plasticity in the spinal cord.
• Protein adsorption isotherm behavior in hydrophobic interaction chromatography.
• Proteomic analysis reveals differences between Vitis vinifera L. cv. Chardonnay and cv. Cabernet Sauvignon and their responses to water deficit and salinity.
• Quantitative proteomics using uniform (15)N-labeling, MASCOT, and the trans-proteomic pipeline.
• Serum Peptide Profiling using MALDI Mass Spectrometry: avoiding the Pitfalls of Coated Magnetic Beads using Well-established ZipTip Technology.
• Structure of the complex of the colicin E2 R-domain and its BtuB receptor. The outer membrane colicin translocon.
• Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation.
• The xenoantibody response and immunoglobulin gene expression profile of cynomolgus monkeys transplanted with hDAF-transgenic porcine hearts.
• Transcript abundance profiles reveal larger and more complex responses of grapevine to chilling compared to osmotic and salinity stress.
• Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens.
• Validation of density functional modeling protocols on experimental bis(mu-oxo)/mu-eta2:eta2-peroxo dicopper equilibria.