Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study.

Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Research Abstract Details 

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Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Abstract Text:

C Neill Epperson,Ralitza Gueorguieva,Kathryn A Czarkowski,Stephanie Stiklus,Edward Sellers,John H Krystal,Douglas L Rothman,Graeme F Mason,

RATIONALE: Childbirth is associated with rapid neuroendocrine fluctuations, which are thought to contribute to the phatogenesis of postpartum major depression (PPD). OBJECTIVES: The aim of this proton magnetic resonance spectroscopy (1H-MRS) study was two-fold; 1) to examine whether puerperium is associated with alterations in occipital cortex gamma-aminobutyric acid (GABA) concentrations and 2) to determine whether such alterations may be more prominent in women with PPD. MATERIALS AND METHODS: Nine women with PPD, 14 postpartum healthy controls, and ten healthy follicular phase females underwent 1H-MRS at 2.1 Tesla to measure occipital cortex GABA concentrations. Postpartum women were scanned within 6 months of delivery and prior to resumption of menstruation. Healthy non-puerperal controls, drawn from a historical sample, were scanned during the early to mid-follicular phase when ovarian hormone levels would be similar to those found in the puerperium. GABA data were analyzed using analysis of covariance, and regression models were used to explore the relationship between cortical GABA concentrations and blood levels of estradiol, progesterone, and neurosteroids. RESULTS: Cortical GABA and plasma allopregnanolone (ALLO) concentrations were reduced in both groups of postpartum women, regardless of PPD diagnosis, compared to healthy follicular phase women. There was no correlation between cortical GABA concentrations and estradiol, progesterone, ALLO, or pregnenolone (PREG). CONCLUSIONS: This study is the first to describe reductions in occipital cortex GABA levels in the postpartum period, a time of increased vulnerability to mood disturbances in women. The concomitant reduction in peripheral ALLO levels provides further evidence of alterations in the balance between cortical excitation and inhibition during the puerperium. Women with PPD may represent a subgroup of women who fail to adequately adapt to this alteration in the neuroendocrine milieu.

Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Publishing Authors By Initials

CN Epperson,R Gueorguieva,KA Czarkowski,S Stiklus,E Sellers,JH Krystal,DL Rothman,GF Mason,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychopharmacology

VOLUME: 186

Page Numbers: 425-33

Journal Abbreviation: Psychopharmacology (Berl.)

ISSN: 0033-3158

DAY: 3

MONTH: 05

YEAR: 2006

Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608025

Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: metabolism

Chemical & Substance for Abstract: Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Information

Substance Name: gamma-Aminobutyric Acid

Registry Number: 56-12-2

Grant and Affiliation Information for Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study.

AFFILIATION: Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06519, USA. neill.epperson@yale.edu

Country: Germany

AGENCY: United States NIMH

GRANT: R01-MH64845

ACRONYM: MH

MEDLINETA: Psychopharmacology (Berl)

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