Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration.

Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration. Abstract Text:

Tien-Min G Chu,Peter Sargent,Stuart J Warden,Charles H Turner,Rena L Stewart,

Large segmental defects in bones can result from tumor removal, massive trauma, congenital malformation, or non-union fractures. Such defects often are difficult to manage and require multiple-phase surgery to achieve adequate union and function. In this study, we propose a novel design of bone morphogenetic protein 2 (BMP-2) carrier for tissue engineering of segmental defect regeneration. The tube-shaped BMP-2 carrier was fabrication from a poly(propylene fumarate)/tricalcium phosphate (PPF/TCP) composite via casting technique developed in our laboratory. An in vitro evaluation showed that the compressive strength of the carrier decreased about 48% in 12 weeks while maintained a pH in the 6.8-7.4 range. In vivo study was conducted by implanting carriers loaded with 10 microg of BMP-2 in 5 mm rat femur gap model for 15 weeks. X-ray evidence of bridging was first found in the BMP group at 3 weeks. Bridging in all animals (N = 4) in the BMP group was found at 9 weeks. No x-ray evidence of bridging was found in the No BMP group (N = 3). pQCT analysis indicated that the bone mineral density of the callus in the BMP group has reached the level of native femur at 15 weeks after implantation, while the callus in the No BMP group has a bone mineral density at a lower level of 84% to the native femur. Histology analysis shows that a normal fatty bone marrow was restored and mineralized callus formed and bridged the segmental defect.

Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration. Publishing Authors By Initials

TM Chu,P Sargent,SJ Warden,CH Turner,RL Stewart,

For similar biomechanics: weight-bearing research abstracts see: biomechanics: weight-bearing research

PUBMED ID PMID:

MEDLINE DATE:

Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomedical sciences instrumentation

VOLUME: 42

Page Numbers: 42-7

Journal Abbreviation:

ISSN: 0067-8856

DAY: 19

MONTH: 11

YEAR: 2006

Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 140524

Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration. Keywords Mesh Terms:

KEYWORDS: Weight-Bearing

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration. Information

Substance Name: bone morphogenetic protein 2

Registry Number: 0

Grant and Affiliation Information for Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration.

AFFILIATION: Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biomed Sci Instrum

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration Related Publications

• A circadian rhythm in the expression of PERIOD2 protein reveals a novel SCN-controlled oscillator in the oval nucleus of the bed nucleus of the stria terminalis.
• A procedure for successful nonsurgical embryo transfer in swine.
• Amperometric determination of hydroxyamphetamine hydrobromide in a flowing stream at the glassy-carbon electrode.
• An assay for methotrexate and its metabolites in serum and urine by ion-pair high-performance liquid chromatography.
• An empirical evaluation of social support and psychological well-being in older Chinese and Korean immigrants.
• Cryoelectron microscopy and EPR analysis of engineered symmetric and polydisperse Hsp16.5 assemblies reveals determinants of polydispersity and substrate binding.
• Estimation of optimal dynamic anticoagulation regimes from observational data: a regret-based approach.
• Evidence-based medicine: A new paradigm for the teaching and practice of medicine.
• Growth factor-induced therapeutic neovascularization for ischaemic vascular disease: time for a re-evaluation?
• Influence of inbreeding on reproductive performance, ejaculate quality and testicular volume in the dog.
• Internet-based behavioral health services in health plans.
• Neuropeptide Y modulation of ethanol intake: effects of ethanol drinking history and genetic background.
• Novel functional association of serine palmitoyltransferase subunit 1-A peptide in sphingolipid metabolism with cytochrome P4501A1 transactivation and proliferative capacity of the human Glioma LN18 brain tumor cell line.
• Off-line automated sample preparation-experience in a clinical drug investigation unit.
• Overview of qualitative methods in research with diverse populations. Making research reflect the population.
• Pharmacokinetics and pharmacodynamics of intravenous epoetin alfa in children with cancer.
• Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420.
• Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration.
• Psychometric characteristics of a patient satisfaction instrument tailored to the concerns of African Americans.
• Psychometric characteristics of the spiritual perspective scale in pregnant African-American women.
• RM1: a reparameterization of AM1 for H, C, N, O, P, S, F, Cl, Br, and I.
• Repeatable focal seizure suppression: a rat preparation to study consequences of seizure activity based on urethane anesthesia and reversible carotid artery occlusion.
• Review of the evidence for the long-term efficacy of atypical antipsychotic agents in the treatment of patients with schizophrenia and related psychoses.
• Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2.
• Specific covalent immobilization of proteins through dityrosine cross-links.
• The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo.
• The enduring and contextual effects of physical health and depression on care-dyad mutuality.
• The laminopathies: the functional architecture of the nucleus and its contribution to disease (*).
• Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor.
• Visualization of alpha-helices in a 6-angstrom resolution cryoelectron microscopy structure of adenovirus allows refinement of capsid protein assignments.