Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia.

Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia. Abstract Text:

V Bonfante,G Bonadonna,F Villani,A Martini,

4'-Epidoxorubicin (epi-DXR) was tested in 56 patients with various types of advanced malignancies. The pattern of acute toxicity was similar to that of doxorubicin (DXR), but epi-DXR produced a lower incidence of vomiting, stomatitis, alopecia, and myelosuppression. The study of cardiac toxicity, utilizing only noninvasive methods, indicated that epi-DXR also is cardiotoxic. The increase in the systolic time intervals after the first dose as well as after cumulative doses was slightly lower compared with that observed after DXR. Antitumor activity occurred in a variety of tumors including malignant melanoma, renal cancer, and rectal cancer, which are refractory to DXR. Present results suggest that further studies with epi-DXR are indicated.

Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia. Publishing Authors By Initials

V Bonfante,G Bonadonna,F Villani,A Martini,

For similar neoplasms research abstracts see: neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 74

Page Numbers: 192-9

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1980

Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 44671

Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia. Information

Substance Name: Epirubicin

Registry Number: 56420-45-2

Grant and Affiliation Information for Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia.

AFFILIATION:

Country: GERMANY, WEST

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Recent Results Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia Related Publications

• 5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.
• Aberrant internal carotid artery in the middle ear: two case reports.
• Acute mastoiditis in children: the "Ferrara" experience.
• Adapted versions of the Sharp/van der Heijde score are reliable and valid for assessment of radiographic progression in juvenile idiopathic arthritis.
• Antiphospholipid syndrome in pediatrics.
• Childhood systemic sclerosis.
• Cytogenetic and array CGH characterization of an intrachromosomal complex rearrangement of 4q in a patient with a 4q-phenotype.
• Differences in the Implementation of Diagnosis-Related Groups across Clinical Departments: A German Hospital Case Study.
• Does calcium supplementation reduce the risk of osteoporotic fracture and bone loss?
• Effects of parathyroidectomy on bone remodeling markers and vitamin D status in patients with chronic kidney disease-mineral and bone disorder.
• Ethanolic extract from Hemidesmus indicus (Linn) displays otoprotectant activities on organotypic cultures without interfering on gentamicin uptake.
• Floating dosage forms to prolong gastro-retention-The characterisation of calcium alginate beads.
• GABA A/Bz receptor subtypes as targets for selective drugs.
• Measuring the psychosocial consequences of hearing loss in a working adult population: focus on validity and reliability of the Italian translation of the hearing handicap inventory.
• Neurological disorders, other than stroke, associated with antiphospholipid antibodies in childhood.
• Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia.
• Prophylactic failure of 1,500 units of tetanus antitoxin; a report of two cases.
• Recent views on the control of anterior pituitary function.
• Regulation of A(2A) adenosine receptor expression and functioning following permanent focal ischemia in rat brain.
• Sprue syndrome with secretory diarrhoea in a 42-year-old woman.
• Temporal bone brain herniation.
• The Paediatric Rheumatology International Trials Organization (PRINTO).
• The provisional Paediatric Rheumatology International Trials Organisation/American College of Rheumatology/european League Against Rheumatism Disease activity core set for the evaluation of response to therapy in juvenile dermatomyositis: A prospective va
• [Factors of growth and metamorphosis of tadpoles. IV. Action of nicotinamide and coumarin.]
• [In Process Citation]
• [Liver cirrhosis after neosalversan therapy.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]