Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro.

Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro. Research Abstract Details 

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Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro. Abstract Text:

Hong Liu,Min Zhao,Catherine A Opere,Hong Liu,Min Zhao,Catherine A Opere,Hong Liu,Min Zhao,Catherine A Opere,

We investigated the effect of isoprostanes (IsoPs) on potassium (K(+))-depolarization-evoked release of [(3)H]dopamine from isolated bovine retinae. Isolated retinae were preloaded with [(3)H]dopamine and then prepared for studies of [(3)H]dopamine release using the superfusion method. 8-iso(15R)PGF(2alpha), 8-isoPGE(2), 8-isoPGE(1) and 8-isoPGF(2alpha) attenuated [(3)H]dopamine release from isolated bovine retinae. At a concentration of 1 muM, the rank order of activity displayed by IsoP agonists was: 8-iso(15R)PGF(2alpha) > 8-isoPGE(2) > 8-isoPGE(1) > 8-isoPGF(2alpha). Inhibition of cyclooxygenase (COX) with flurbiprofen reversed the effects caused by 8-isoPGE(2) (10 nM and 10 muM), 8-iso(15R)PGF(2alpha) (1 muM) and 8-isoPGE(1) (1 muM). Although the EP1/EP2 antagonist, AH 6809 (10 muM) had no significant effect on K(+)-induced [(3)H]dopamine release, it blocked the inhibitory effect of both 8-isoPGE(1) (10 muM) and 8-isoPGE(2) (10 muM). In conclusion, IsoPs attenuate K(+)-induced [(3)H]dopamine release in isolated bovine retinae, presumably via an indirect action on COX pathway leading to the production of prostanoids, which in turn, activates EP receptors.

Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro. Publishing Authors By Initials

H Liu,M Zhao,CA Opere,H Liu,M Zhao,CA Opere,H Liu,M Zhao,CA Opere,

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Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurochemical research

VOLUME: 33

Page Numbers: 37-42

Journal Abbreviation: Neurochem. Res.

ISSN: 0364-3190

DAY: 3

MONTH: 08

YEAR: 2007

Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro. Information

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LANGUAGE: eng

NlmUniqueID: 7613461

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AFFILIATION: Department of Ophthalmology, Sichuan Provincial People Hospital, Chengdu, Sichuan , 610072, P.R. China.

Country: United States

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MEDLINETA: Neurochem Res

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