Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus.

Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Research Abstract Details 

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Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Abstract Text:

Gwonhwa Song,Fuller W Bazer,Thomas E Spencer,

Radical S-adenosyl methionine domain containing 2 (RSAD2) encodes a cytoplasmic antiviral protein induced by interferons (IFN). Interferon-induced with helicase C domain 1 (IFIH1) is a RNA helicase involved in innate immune defense against viruses, growth suppression, and apoptosis. Interferon tau (IFNT), a Type I IFN produced by the peri-implantation ruminant conceptus, acts on the uterine endometrium to signal pregnancy recognition and promote receptivity to implantation. Transcriptional profiling identified RSAD2 and IFIH1 as IFNT regulated genes in the ovine uterine endometrium. This study tested the hypothesis that RSAD2 and IFIH1 were induced in the endometrium in a cell type-specific manner by IFNT from the conceptus during early pregnancy. Endometrial RSAD2 and IFIH1 mRNA increased between days 12 and 16 of pregnancy, but not of the estrous cycle. In pregnant ewes, RSAD2 and IFIH1 mRNAs increased in endometrial glands, and stroma and immune cells, but not in the luminal epithelium. Neither gene was expressed in the trophectoderm of day 18 or 20 conceptuses. Progesterone (P4) treatment of ovariectomized ewes did not induce expression RSAD2 or IFIH1 mRNA in the endometrium; however, intrauterine injections of IFNT induced expression of RSAD2 and IFIH1 mRNA in endometria of ewes treated with P4, as well as in ewes treated with P4 and the progesterone receptor antagonist, ZK 136,317. These results indicate that conceptus IFNT induces both RSAD2 and IFIH1 in a P4-independent manner in the ovine uterine endometrium. These two IFNT-stimulated genes are proposed to have biological roles in the establishment of uterine receptivity to the conceptus during implantation through induction of an antiviral state and modulation of local immune cells in the endometrium.

Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Publishing Authors By Initials

G Song,FW Bazer,TE Spencer,

For similar animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep research

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Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Reproduction (Cambridge, England)

VOLUME: 133

Page Numbers: 285-95

Journal Abbreviation: Reproduction

ISSN: 1470-1626

DAY: 3

MONTH: Jan

YEAR: 2007

Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100966036

Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Keywords Mesh Terms:

KEYWORDS: Sheep

MESH TERMS: metabolism

Chemical & Substance for Abstract: Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Information

Substance Name: RNA Helicases

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus.

AFFILIATION: Center for Animal Biotechnology and Genomics, Texas A&M University, 442 Kleberg Center, 2471 TAMU, College Station, Texas 77843-2471, USA.

Country: England

AGENCY: United States NICHD

GRANT: 5 R01 HD32534

ACRONYM: HD

MEDLINETA: Reproduction

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