Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders.

Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders. Research Abstract Details 

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Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders. Abstract Text:

Guy G Potter,Andrew D Blackwell,Douglas R McQuoid,Martha E Payne,David C Steffens,Barbara J Sahakian,Kathleen A Welsh-Bohmer,K R Ranga Krishnan,

Poor task persistence is often observed among depressed individuals, and may be associated with some of the same frontal regions that are involved in depression. The current study explored the association between white-matter lesion volume in prefrontal cortex and noncompletion rates on a complex neurocognitive task among older adults in a treatment study for depression. Older adults in treatment for depression (n=83) and nondepressed (n=47) elders were administered the Stockings of Cambridge subtest (SoC) of the Cambridge Automated Neuropsychological Testing Battery (CANTAB) and completed a brain magnetic resonance imaging scan as part of an ongoing research study. Noncompletion of the SoC occurred in approximately 19% of depressed participants (16/83) and only 2% of nondepressed participants (1/47), which was statistically significant. In multivariate models, failure to complete the SoC was consistently and significantly associated with greater volume of white matter lesions in the anterior-most region of prefrontal cortex, particularly in the left hemisphere, and with greater age. Although SoC completion was not significantly associated with depression severity, noncompletion rates were significantly higher among unremitted individuals and those with comorbid anxiety at study entry. The inability to initiate behavior sufficient to sustain a complex neurocognitive task is a characteristic of geriatric depression which may be associated with integrity of left-prefrontal regions. Future research should investigate whether task impersistence is a construct that generalizes to other neurocognitive tasks, and if it is associated with other adverse outcomes in geriatric depression related to cerebrovascular pathology, such as poor treatment response.

Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders. Publishing Authors By Initials

GG Potter,AD Blackwell,DR McQuoid,ME Payne,DC Steffens,BJ Sahakian,KA Welsh-Bohmer,KR Krishnan,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: frontal lobe: prefrontal cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: frontal lobe: prefrontal cortex research

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Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropsychopharmacology : official publication of

VOLUME: 32

Page Numbers: 2135-42

Journal Abbreviation: Neuropsychopharmacology

ISSN: 0893-133X

DAY: 14

MONTH: 02

YEAR: 2007

Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders. Information

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LANGUAGE: eng

NlmUniqueID: 8904907

Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders. Keywords Mesh Terms:

KEYWORDS: Prefrontal Cortex

MESH TERMS: physiopathology

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Grant and Affiliation Information for Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders.

AFFILIATION: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. guy.potter@duke.edu

Country: United States

AGENCY: United Kingdom Wellcome T

GRANT: R01 MH54846

ACRONYM: MH

MEDLINETA: Neuropsychopharmacology

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