Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder.

Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Research Abstract Details 

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Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Abstract Text:

K Matsuo,D C Glahn,M A M Peluso,J P Hatch,E S Monkul,P Najt,M Sanches,F Zamarripa,J Li,J L Lancaster,P T Fox,J-H Gao,J C Soares,

The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation of mood, cognition and behavior and has been implicated in the pathophysiology of major depressive disorder (MDD). Many neuropsychological studies demonstrate impairment of working memory in patients with MDD. However, there are few functional neuroimaging studies of MDD patients during working memory processing, and most of the available ones included medicated patients or patients with both MDD and bipolar disorder. We used functional magnetic resonance imaging (fMRI) to measure prefrontal cortex function during working memory processing in untreated depressed patients with MDD. Fifteen untreated individuals with Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition recurrent MDD (mean age+/-s.d.=34.3+/-11.5 years) and 15 healthy comparison subjects (37.7+/-12.1 years) matched for age, sex and race were studied using a GE/Elscint 2T MR system. An echo-planar MRI sequence was used to acquire 24 axial slices. The n-back task (0-back, 1-back and 2-back) was used to elicit frontal cortex activation. Data were analyzed with a multiple regression analysis using the FSL-FEAT software. MDD patients showed significantly greater left dorsolateral cortex activation during the n-back task compared to the healthy controls (P<0.01), although task performance was similar in the two groups. Furthermore, the patients showed significant anterior cingulate cortex activation during the task, but the comparison subjects did not (P<0.01). This study provides in vivo imaging evidence of abnormal frontolimbic circuit function during working memory processing in individuals with MDD.

Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Publishing Authors By Initials

K Matsuo,DC Glahn,MA Peluso,JP Hatch,ES Monkul,P Najt,M Sanches,F Zamarripa,J Li,JL Lancaster,PT Fox,JH Gao,JC Soares,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: frontal lobe: prefrontal cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: frontal lobe: prefrontal cortex research

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Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Molecular psychiatry

VOLUME: 12

Page Numbers: 158-66

Journal Abbreviation: Mol. Psychiatry

ISSN: 1359-4184

DAY: 19

MONTH: 09

YEAR: 2006

Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Information

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LANGUAGE: eng

NlmUniqueID: 9607835

Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Keywords Mesh Terms:

KEYWORDS: Prefrontal Cortex

MESH TERMS: physiopathology

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Grant and Affiliation Information for Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder.

AFFILIATION: MOOD-CNS Program, Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.

Country: England

AGENCY: United States NCRR

GRANT: RR020571

ACRONYM: RR

MEDLINETA: Mol Psychiatry

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