Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues.

Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues. Research Abstract Details 

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Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues. Abstract Text:

Hideaki Takagi,Naomichi Furuya,Naoya Kojima,Hideaki Takagi,Naomichi Furuya,Naoya Kojima,Hideaki Takagi,Naomichi Furuya,Naoya Kojima,

The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coated liposomes (oligomannose-coated liposome, OMLs) into the peritoneal cavity of mice resulted in specific and rapid incorporation of OMLs into PEMs. Upon OML incorporation, expression of co-stimulatory molecules, CD40, CD80, and CD86, and of MHC class II molecules was clearly enhanced on PEMs. In addition, production of IL-12 from PEMs was clearly promoted in response to OML incorporation, while those of IL-1 and IL-6 were suppressed. In contrast, liposomes coated with other carbohydrates and those without a carbohydrate-coating did not induce production of these cytokines. The cytokine profile produced from PEMs in response to OML clearly differed from those in response to ligands for TLRs, in which productions of IL-1 and/or IL-6 were strongly enhanced. Taken together, the results indicate that OMLs activate PEMs through a particular type of signal pathway distinct from those activated with TLR ligands, leading to specific production of IL-12 and consequent maturation of PEMs. Thus, OMLs can be used as a novel adjuvant for efficient activation of specific cellular immunity.

Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues. Publishing Authors By Initials

H Takagi,N Furuya,N Kojima,H Takagi,N Furuya,N Kojima,H Takagi,N Furuya,N Kojima,

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Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cytokine

VOLUME: 40

Page Numbers: 241-50

Journal Abbreviation: Cytokine

ISSN: 1043-4666

DAY: 3

MONTH: 12

YEAR: 2007

Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues.

AFFILIATION: Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259-1292, Japan.

Country: United States

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MEDLINETA: Cytokine

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