[Prefabrication of vascularized bone flap using bone morphogenetic protein (BMP)]

[Prefabrication of vascularized bone flap using bone morphogenetic protein (BMP)] Research Abstract Details 

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[Prefabrication of vascularized bone flap using bone morphogenetic protein (BMP)] Abstract Text:

M Oda,

The purpose of this study was to produce newly vascularized bone, and to form the bone into the desired shape. Silicone molds given the shape of a cylinder were used to deliver collagen sheets impregnated with or without rhBMP-2. The superficial inferior epigastric neurovascular bundle in a Wistar rat was identified and sandwiched between the silicone molds. The molds containing collagen sheets impregnated with 10 micrograms of rhBMP-2 were used for the experimental purpose, and those without rhBMP-2 were used as a control. In some of the experimental molds, the neurovascular bundle was ligated at both proximal and distal sites of the molds. After 2 and 4 weeks operation, bone formation was detected macroscopically, radiologically, and histologically. As a result, newly formed bone was observed in all experimental sites without the ligation, and the shape of the bone was exactly the same shape as the silicone mold. Newly formed bone was supplied by the superficial inferior epigastric artery, whereas newly formed bone was not observed in the control and the ligated flaps. Newly vascularized and shaped bone was created by applying an osteoinductive factor to a neurovascular bundle. This study demonstrates that this experimental model could be a therapeutically potential approach for effective bone reconstruction.

[Prefabrication of vascularized bone flap using bone morphogenetic protein (BMP)] Publishing Authors By Initials

M Oda,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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[Prefabrication of vascularized bone flap using bone morphogenetic protein (BMP)] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: K?k?by? Gakkai zasshi. The Journal of the Stomatol

VOLUME: 68

Page Numbers: 134-40

Journal Abbreviation: Kokubyo Gakkai Zasshi

ISSN: 0300-9149

DAY: 19

MONTH: Mar

YEAR: 2001

[Prefabrication of vascularized bone flap using bone morphogenetic protein (BMP)] Information

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LANGUAGE: jpn

NlmUniqueID: 413677

[Prefabrication of vascularized bone flap using bone morphogenetic protein (BMP)] Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: [Prefabrication of vascularized bone flap using bone morphogenetic protein (BMP)] Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for [Prefabrication of vascularized bone flap using bone morphogenetic protein (BMP)]

AFFILIATION: Department of Oral Restitution, Division of Oral Health Science, Tokyo Medical and Dental University, Graduate School.

Country: Japan

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MEDLINETA: Kokubyo Gakkai Zasshi

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