Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus.

Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus. Research Abstract Details 

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Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus. Abstract Text:

H Sawhney,J Weedon,P Gillette,W Solomon,A Braverman,

BACKGROUND: Ischemic ulcers are usually found above the lateral, and venous stasis ulcers at the medial malleoli. Leg ulcers occur in at least 25% of sickle cell disease (SSD) patients in clinic populations, usually in the malleolar region. The function of the large leg veins in most SSD patients is unimpaired. PATIENTS AND METHODS: We determined leg ulcer location in 41 sickle cell anemia (SS), and 4 sickle-beta 0 thalassemic patients with longstanding chronic and/or recurrent leg ulceration, and reviewed published reports of leg ulcers in hereditary spherocytosis and thalassemias. RESULTS: Of the 57 legs of the 45 SSD patients with only 1 ulcer, 42 (74%) were medial and 15 lateral. The difference was significant (p < 0.001). Of patients with only a single ulcer, 22 were medial and 4 lateral. Of 15 reported patients with leg ulcers related to spherocytosis or thalassemia, 20/24 (83%) ulcers were medial. CONCLUSIONS: The medial malleoli are the most common site of leg ulceration in SSD and in other chronic hemolytic anemias. This suggests that stasis may play a role in the leg ulceration associated with chronic hemolytic anemia.

Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus. Publishing Authors By Initials

H Sawhney,J Weedon,P Gillette,W Solomon,A Braverman,

For similar hemic and lymphatic diseases: hematologic diseases: anemia: anemia, hemolytic: anemia, hemolytic, congenital: thalassemia: beta-thalassemia research abstracts see: hemic and lymphatic diseases: hematologic diseases: anemia: anemia, hemolytic: anemia, hemolytic, congenital: thalassemia: beta-thalassemia research

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Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: VASA. Zeitschrift für Gefässkrankheiten. Journal f

VOLUME: 31

Page Numbers: 191-3

Journal Abbreviation: VASA

ISSN: 0301-1526

DAY: 13

MONTH: Aug

YEAR: 2002

Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus. Information

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LANGUAGE: eng

NlmUniqueID: 317051

Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus. Keywords Mesh Terms:

KEYWORDS: beta-Thalassemia

MESH TERMS: complications

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Grant and Affiliation Information for Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus.

AFFILIATION: Division of Hematology-Oncology, Health Sciences Center at Brooklyn, State University of New York, USA.

Country: Switzerland

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MEDLINETA: Vasa

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