Predictors of seizure onset in Rett syndrome.

Predictors of seizure onset in Rett syndrome. Research Abstract Details 

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Predictors of seizure onset in Rett syndrome. Abstract Text:

Le Jian,Lakshmi Nagarajan,Nicholas de Klerk,David Ravine,Carol Bower,Alison Anderson,Sarah Williamson,John Christodoulou,Helen Leonard,

OBJECTIVES: To investigate risk factors for seizure onset in Rett syndrome. STUDY DESIGN: Information on presence and age at onset of seizures, perinatal and developmental history, and genetic status was abstracted on 275 cases in the Australian Rett Syndrome Database. Cox and Weibull regression were used to investigate and provide a model for predicting the effects of genetic and developmental factors on age at seizure onset. RESULTS: Seizures were reported in 81% of 275 cases; the median age of onset was 48 months. Not having gained the ability to walk (P = .003) and developmental problems in the first 10 months of age (P = .04) were associated with an almost 2-fold increased risk of seizures. Cases without a detectable MECP2 mutation had a higher risk of seizure onset up to 4 years of age (P < .001) but a lower risk after 4 years (P = .08). CONCLUSIONS: Seizure onset in Rett syndrome is associated with early developmental factors and with genotype. Information on these factors can be used to predict age at seizure onset after diagnosis.

Predictors of seizure onset in Rett syndrome. Publishing Authors By Initials

L Jian,L Nagarajan,N de Klerk,D Ravine,C Bower,A Anderson,S Williamson,J Christodoulou,H Leonard,

For similar nervous system diseases: central nervous system diseases: brain diseases: epilepsy: seizures research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: epilepsy: seizures research

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Predictors of seizure onset in Rett syndrome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of pediatrics

VOLUME: 149

Page Numbers: 542-7

Journal Abbreviation: J. Pediatr.

ISSN: 0022-3476

DAY: 3

MONTH: Oct

YEAR: 2006

Predictors of seizure onset in Rett syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 375410

Predictors of seizure onset in Rett syndrome. Keywords Mesh Terms:

KEYWORDS: Seizures

MESH TERMS: genetics

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Grant and Affiliation Information for Predictors of seizure onset in Rett syndrome.

AFFILIATION: Centre for Child Health Research, The University of Western Australia, Telethon Institute for Child Health Research, Perth, Western Australia, Australia.

Country: United States

AGENCY: United States NICHD

GRANT: 1-R01-HD43100-01A1

ACRONYM: HD

MEDLINETA: J Pediatr

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