Predictors of left ventricular dilatation in young adults (from the Bogalusa Heart Study).

Predictors of left ventricular dilatation in young adults (from the Bogalusa Heart Study). Research Abstract Details 

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Predictors of left ventricular dilatation in young adults (from the Bogalusa Heart Study). Abstract Text:

Showkat A Haji,Rifat Eralp Ulusoy,Dharmendrakumar A Patel,Sathanur R Srinivasan,Wei Chen,Patrice Delafontaine,Gerald S Berenson,

Left ventricular (LV) dilatation may be an early sign of cardiac decompensation progressing to LV dysfunction. Determinants of LV dilatation in young asymptomatic adults are unknown. Five hundred six asymptomatic subjects (mean age 32 +/- 3 years) enrolled in the Bogalusa Heart Study underwent echocardiographic examination. LV dilatation (LV end-diastolic diameter >5.5 cm) as measured by M-mode echocardiography was found in 31 subjects (6%). Subjects with LV dilatation had greater body mass indexes (32 +/- 9 vs 27 +/- 6 kg/m2, p <0.0001), systolic (119 +/- 15 vs 112 +/- 12 mm Hg, p = 0.007) and diastolic (79 +/- 12 vs 75 +/- 9 mm Hg, p = 0.04) blood pressures, and LV mass (230 +/- 50 vs 123 +/- 39 g, p <0.0001). Age, gender, race, and metabolic parameters (glucose, insulin, and lipoprotein levels) did not differ significantly between the subjects with and without LV dilatation. After correction for age, gender, and race differences, adulthood obesity (body mass index >30 kg/m2) was associated with a threefold odds ratio (2.9, 95% confidence interval 1.4 to 6.1), and hypertension (defined as per the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure) was also associated with a threefold odds ratio (3.0, 95% confidence interval 1.2 to 7.1) for an increased incidence of LV dilatation. There was an incremental increase in LV end-diastolic dimension depending on the presence of hypertension or obesity, and subjects with obesity and hypertension in adulthood had the greatest degree of LV end-diastolic dimensions. In multiple regression analyses, body mass index in childhood was the only significant predictor of LV dilatation in adulthood (odds ratio 1.47, 95% confidence interval 1.03 to 2.09). In conclusion, obesity beginning in childhood and obesity and hypertension in young adulthood are predictors of LV dilatation in an otherwise healthy young adult population.

Predictors of left ventricular dilatation in young adults (from the Bogalusa Heart Study). Publishing Authors By Initials

SA Haji,RE Ulusoy,DA Patel,SR Srinivasan,W Chen,P Delafontaine,GS Berenson,

For similar cardiovascular diseases: heart diseases: ventricular dysfunction: ventricular dysfunction, left research abstracts see: cardiovascular diseases: heart diseases: ventricular dysfunction: ventricular dysfunction, left research

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Predictors of left ventricular dilatation in young adults (from the Bogalusa Heart Study). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of cardiology

VOLUME: 98

Page Numbers: 1234-7

Journal Abbreviation: Am. J. Cardiol.

ISSN: 0002-9149

DAY: 7

MONTH: 09

YEAR: 2006

Predictors of left ventricular dilatation in young adults (from the Bogalusa Heart Study). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 207277

Predictors of left ventricular dilatation in young adults (from the Bogalusa Heart Study). Keywords Mesh Terms:

KEYWORDS: Ventricular Dysfunction, Left

MESH TERMS: ultrasonography

Chemical & Substance for Abstract: Predictors of left ventricular dilatation in young adults (from the Bogalusa Heart Study). Information

Substance Name: Biological Markers

Registry Number: 0

Grant and Affiliation Information for Predictors of left ventricular dilatation in young adults (from the Bogalusa Heart Study).

AFFILIATION: Department of Cardiology, Medical Center, Tulane University, New Orleans, Louisiana, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-38844

ACRONYM: HL

MEDLINETA: Am J Cardiol

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