Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins.

Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins. Abstract Text:

Masanori Matsuda,Tetsuya Suzuki,Hiroshi Kono,Hideki Fujii,Masanori Matsuda,Tetsuya Suzuki,Hiroshi Kono,Hideki Fujii,

PURPOSE: In this study, we tried to identify the preoperative predictors of hepatic venous trunk invasion and the prognostic factors in patients with hepatocellular carcinoma (HCC) that had come into contact with the trunk of a major hepatic vein over a distance of 1.0 cm or more. METHODS: Forty patients who had such HCCs resected were entered into this study and predictors of hepatic venous trunk invasion and prognostic factors were evaluated by univariate and multivariate analyses. RESULTS AND CONCLUSIONS: A combined resection of the HCC and the venous trunk was performed in 29 patients. Hepatic venous trunk invasion was observed in 12 patients, including 2 with inferior vena cava tumor thrombus. A stepwise logistic regression analysis indicated that tumors larger than or equal to 7 cm in diameter and tumors showing a poorly differentiated histological grade were independent predictors of hepatic venous trunk invasion. The survival of patients without venous trunk invasion was significantly better than that for patients with venous trunk invasion (P = 0.048). A univariate analysis revealed that Child-Pugh classification B (P = 0.002), a high des-gamma-carboxy prothrombin concentration (> or =400 mAU/ml, P = 0.023), a large HCC (> or =5.0 cm in diameter, P = 0.002), the presence of portal vein invasion (P < 0.001), the presence of venous trunk invasion (P = 0.048), the presence of intrahepatic metastasis (P < 0.001), and poorly differentiated HCC (P = 0.006) correlated with a worse overall survival after hepatic resection. In a multivariate analysis, however, only the presence of intrahepatic metastasis (P = 0.037, relative risk 8.25) was an independent predictor of poor overall survival. CONCLUSIONS: Large tumors (> or =7 cm in diameter) and poorly differentiated HCCs were more likely to be associated with hepatic venous trunk invasion and intrahepatic metastasis was an independent prognostic factor in patients with HCC that had come into contact with the trunk of a major hepatic vein.

Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins. Publishing Authors By Initials

M Matsuda,T Suzuki,H Kono,H Fujii,M Matsuda,T Suzuki,H Kono,H Fujii,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of hepato-biliary-pancreatic surgery

VOLUME: 14

Page Numbers: 289-96

Journal Abbreviation:

ISSN: 0944-1166

DAY: 29

MONTH: 05

YEAR: 2007

Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9431940

Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins.

AFFILIATION: First Department of Surgery, Yamanashi University School of Medicine, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Hepatobiliary Pancreat Surg

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins Related Publications

• CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer.
• Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.
• Characterization of neutral fragments issued from the photodissociation of protonated tryptophane.
• Comprehensive characterization of the photodissociation pathways of protonated tryptophan.
• Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line.
• Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells.
• Development of multilocus single strand conformation polymorphism (MLSSCP) analysis of virulence genes of Listeria monocytogenes and comparison with existing DNA typing methods.
• Dissimilatory iodate reduction by marine Pseudomonas sp. strain SCT.
• Effects of BCAA Supplementation on Makers of Muscle Damage and Inflammation during Low-Intensity Prolonged Exercise: 2070: Board #140 May 31 3:30 PM 5:00 PM.
• Effects of smoking on odour identification in Japanese subjects.
• Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma.
• High prevalence of erythromycin resistance and macrolide-resistance genes, mefA and ermB, in Streptococcus pneumoniae isolates from the upper respiratory tracts of children in the Sapporo district, Japan.
• Hydrogen desorption mechanism in a Li-N-H system by means of the isotopic exchange technique.
• In situ observation of phase transformation in an Fe-Zn system at high temperatures using an image plate.
• Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein.
• Isolation and characterization of mammalian D-aspartyl endopeptidase.
• Lacunar skull deformity and hydrocephalus in infants with myelomeningocele: is lacunar skull deformity a predictor of hydrocephalus development?
• Late intrathoracic relapse of pineal germinoma connected to intraspinal canal.
• Nras and Kras mutation in Japanese lung cancer patients: Genotyping analysis using LightCycler.
• Nuclear translocation of 2-amino-3-ketobutyrate coenzyme A ligase by cold and osmotic stress.
• PIK3CA gene amplification in Japanese non-small cell lung cancer.
• Phytoestrogens from Aspalathus linearis.
• Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins.
• Primary malignant lymphoma of the cranial vault.
• Prognostic value of Ki-67 (MIB-1) and p53 in ependymomas.
• Ranitidine-induced drug eruption: another case of papuloerythroderma?
• Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon.
• Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase.
• Secretin-stimulating MRCP in patients with pancreatobiliary maljunction and occult pancreatobiliary reflux: direct demonstration of pancreatobiliary reflux.
• Temporal regulation of Stat5 activity in determination of cell differentiation program.