Predictors of congestive heart failure in patients on maintenance hemodialysis.

Predictors of congestive heart failure in patients on maintenance hemodialysis. Research Abstract Details 

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Predictors of congestive heart failure in patients on maintenance hemodialysis. Abstract Text:

Shigenori Ito,Sumiko Murai,Masato Sugiura,Takayuki Yoshida,Tatsuya Fukutomi,Shigenori Ito,Sumiko Murai,Masato Sugiura,Takayuki Yoshida,Tatsuya Fukutomi,

BACKGROUND: Cardiovascular disease is a major cause of death in patients on maintenance hemodialysis (HD). Predictors of congestive heart failure (CHF) events in patients on HD were investigated, focusing on left ventricular (LV) function. METHODS AND RESULTS: One hundred consecutive patients on HD were followed for at least 5 years after index examination performed 1 day after the last HD session. Tests included M-mode and Doppler echocardiography and plasma brain natriuretic peptide (BNP) and hemoglobin (Hb) concentration measurements. Patients with atrial fibrillation or poor echocardiographic images were excluded. Confounding factors included diabetes mellitus (DM), hypertension, age, HD duration, LV fractional shortening, E/A of transmitral flow velocity pattern, Tei index, LV mass index (LVMI), BNP level, Hb, and use of antihypertensive or antiarrhythmic drugs. Six CHF events occurred during 1,703+/-565 days. DM and Hb <10 g/dl were identified as independent predictors of CHF events in a stepwise Cox regression model after DM, LVMI, BNP, and Hb <10 g/dl were selected in the univariate analysis. The hazard ratio (confidence interval) was 10.96 (1.49-80.44) for DM, and 23.00 (2.41-219.76) for Hb <10 g/dl. The estimated hazard across time was constant (T_COV*DM; p=0.726, T_COV*Hb <10 g/dl; p=0.681) by time-dependent covariates analysis. CONCLUSION: In patients on maintenance HD, DM and anemia (Hb <10 g/dl), but not echo-derived cardiac function, predicted CHF events.

Predictors of congestive heart failure in patients on maintenance hemodialysis. Publishing Authors By Initials

S Ito,S Murai,M Sugiura,T Yoshida,T Fukutomi,S Ito,S Murai,M Sugiura,T Yoshida,T Fukutomi,

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Predictors of congestive heart failure in patients on maintenance hemodialysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Circulation journal : official journal of the Japa

VOLUME: 71

Page Numbers: 1424-9

Journal Abbreviation: Circ. J.

ISSN: 1346-9843

DAY: 27

MONTH: Sep

YEAR: 2007

Predictors of congestive heart failure in patients on maintenance hemodialysis. Information

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LANGUAGE: eng

NlmUniqueID: 101137683

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AFFILIATION: Division of Cardiology, Nagoya City Moriyama Municipal Hospital, Nagoya, Japan. shigeito5@hotmail.com

Country: Japan

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MEDLINETA: Circ J

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