Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis.

Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis. Research Abstract Details 

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Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis. Abstract Text:

Minoru Nakamura,Atsumasa Komori,Masahiro Ito,Hisayoshi Kondo,Yoshihiro Aiba,Kiyoshi Migita,Shinya Nagaoka,Kazuyuki Ohata,Koji Yano,Seigo Abiru,Manabu Daikoku,Hiroshi Yatsuhashi,Shinji Shimoda,Hiromi Ishibashi,Minoru Nakamura,Atsumasa Komori,Masahiro Ito,Hisayoshi Kondo,Yoshihiro Aiba,Kiyoshi Migita,Shinya Nagaoka,Kazuyuki Ohata,Koji Yano,Seigo Abiru,Manabu Daikoku,Hiroshi Yatsuhashi,Shinji Shimoda,Hiromi Ishibashi,

Because some of the autoreactive T-cell clones specific for human PDC-E2 cross-react to mimicry peptides having an EIExDK motif derived from nuclear antigens such as human gp210 and sp100, we studied the clinical significance of antinuclear antibodies (ANA) in primary biliary cirrhosis (PBC) patients registered to the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ). We found that there are two different types of progression in PBC; one is a hepatic failure-type progression which is represented by positive anti-gp210 antibodies and the other is a portalhypertension-type progression which is represented by positive anticentromere antibodies. We discuss the predictive role of these ANA in the long-term outcome of PBC and the mechanisms by which two different PBC progression types occur based on molecular mimicry and aberrant expression of nuclear antigens.

Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis. Publishing Authors By Initials

M Nakamura,A Komori,M Ito,H Kondo,Y Aiba,K Migita,S Nagaoka,K Ohata,K Yano,S Abiru,M Daikoku,H Yatsuhashi,S Shimoda,H Ishibashi,M Nakamura,A Komori,M Ito,H Kondo,Y Aiba,K Migita,S Nagaoka,K Ohata,K Yano,S Abiru,M Daikoku,H Yatsuhashi,S Shimoda,H Ishibashi,

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Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 37 Suppl 3

Page Numbers: S412-9

Journal Abbreviation: Hepatol. Res.

ISSN: 1386-6346

DAY: 12

MONTH: Oct

YEAR: 2007

Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis. Information

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LANGUAGE: eng

NlmUniqueID: 9711801

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AFFILIATION: National Hospital Organization (NHO) Nagasaki Medical Center, Omura; Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Fukuoka, Japan.

Country: Netherlands

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MEDLINETA: Hepatol Res

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