Predictive risk factors for coronary artery abnormalities in Kawasaki disease.

Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Research Abstract Details 

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Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Abstract Text:

Taeyeun Kim,Wooksun Choi,Chan-Wook Woo,Byungmin Choi,Junghwa Lee,Kwangchul Lee,Changsung Son,Joowon Lee,

Clinical characteristics to predict the development of coronary artery abnormalities (CAA) in Kawasaki disease (KD) were assessed by reviewing medical records of patients diagnosed with KD at Korea University Medical Center from March 2001 to February 2005. Of the 285 patients diagnosed with KD, 19 developed CAA (6.7%). Compared with the CAA(-) group, the CAA(+) group had a longer duration of fever after intravenous gamma-globulin (IVGG) injection (2.4+/-2.9 vs. 1.5+/-1.2 days, p=0.008) and higher C-reactive protein (CRP)(12.3+/-7.8 vs. 8.7+/-7.1 mg/dL, p=0.038). In particular, the CAA(+) group tended to have more than 7 days of fever before IVGG and more than 3 days of fever after IVGG (26.3 vs. 5.3%, p<0.001; 26.3 vs. 6.4%, p=0.002). When the IVGG responsiveness was defined by the presence of defervescence within 3 days after IVGG, IVGG-non-responders showed a higher incidence of CAA (22.7 vs. 5.3%, p=0.002). Non-responders had a longer duration of fever after IVGG (5.5+/-1.9 vs. 1.2+/-0.6 days, p<0.001) and a significantly increased CRP, AST, ALT and total bilirubin. Multivariate regression analysis for CAA showed that the only factor significantly associated with the development of CAA was total fever that lasted for longer than 8 days (OR=4.052, 95% CI=1.151-14.263, p=0.0293). Conclusively, the most important predictor of CAA in KD is total duration of fever longer than 8 days. Early identification of IVGG non-responders and active therapeutic intervention for fever in KD cases might decrease the incidence of CAA.

Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Publishing Authors By Initials

T Kim,W Choi,CW Woo,B Choi,J Lee,K Lee,C Son,J Lee,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pediatrics

VOLUME: 166

Page Numbers: 421-5

Journal Abbreviation: Eur. J. Pediatr.

ISSN: 0340-6199

DAY: 11

MONTH: 10

YEAR: 2006

Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Information

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LANGUAGE: eng

NlmUniqueID: 7603873

Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Information

Substance Name: Immunoglobulins, Intravenous

Registry Number: 0

Grant and Affiliation Information for Predictive risk factors for coronary artery abnormalities in Kawasaki disease.

AFFILIATION: Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea.

Country: Germany

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MEDLINETA: Eur J Pediatr

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