Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience.

Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience. Abstract Text:

Sophie Park,Sophie Grabar,Charikleia Kelaidi,Odile Beyne-Rauzy, Picard, Bardet, Coiteux, Leroux,Pascale Lepelley, Daniel, Cheze, ,Augustin Ferrant,Christophe Ravoet,Martine Escoffre-Barbe,Lionel ,Norbert Vey,Lina Aljassem,Aspasia Stamatoullas,Lionel Mannone, Dombret,Keith Bourgeois,Peter Greenberg,Pierre Fenaux, Dreyfus, ,Sophie Park,Sophie Grabar,Charikleia Kelaidi,Odile Beyne-Rauzy,Françoise Picard,Valérie Bardet,Valérie Coiteux,Geneviève Leroux,Pascale Lepelley,Marie-Thérèse Daniel,Stéphane Cheze,Béatrice Mahé,Augustin Ferrant,Christophe Ravoet,Martine Escoffre-Barbe,Lionel Adès,Norbert Vey,Lina Aljassem,Aspasia Stamatoullas,Lionel Mannone,Hervé Dombret,Keith Bourgeois,Peter Greenberg,Pierre Fenaux,François Dreyfus, ,

We analyzed prognostic factors of response, response duration, and possible impact on survival of epoetin alpha, epoetin beta, or darbepoetin alpha (DAR) with or without granulocyte colony-stimulating factor in 403 myelodysplastic syndrome (MDS) patients. Sixty-two percent (40% major and 22% minor) and 50% erythroid responses were seen, and median response duration was 20 and 24 months according to IWG 2000 and 2006 criteria, respectively. Significantly higher response rates were observed with less than 10% blasts, low and int-1 International Prognostic Scoring System (IPSS), red blood cell transfusion independence, serum EPO level less than 200 IU/L, and, with IWG 2006 criteria only, shorter interval between diagnosis and treatment. Significantly longer response duration was associated with major response (IWG 2000 criteria), IPSS low to INT-1, blasts less than 5%, and absence of multilineage dysplasia. Minor responses according to IWG 2000 were reclassified as "nonresponders" or "responders" according to IWG 2006 criteria. However, among those IWG 2000 minor responders, response duration did not differ between IWG 2006 responders and nonresponders. Multivariate adjusted comparisons of survival between our cohort and the untreated MDS cohort used to design IPSS showed similar rate of progression to acute myeloid leukemia in both cohorts, but significantly better overall survival in our cohort, suggesting that epoetin or DAR treatment may have a favorable survival impact in MDS.

Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience. Publishing Authors By Initials

S Park,S Grabar,C Kelaidi,O Beyne-Rauzy,F Picard,V Bardet,V Coiteux,G Leroux,P Lepelley,MT Daniel,S Cheze,B ,A Ferrant,C Ravoet,M Escoffre-Barbe,L ,N Vey,L Aljassem,A Stamatoullas,L Mannone,H Dombret,K Bourgeois,P Greenberg,P Fenaux,F Dreyfus, ,S Park,S Grabar,C Kelaidi,O Beyne-Rauzy,F Picard,V Bardet,V Coiteux,G Leroux,P Lepelley,MT Daniel,S Cheze,B Mahé,A Ferrant,C Ravoet,M Escoffre-Barbe,L Adès,N Vey,L Aljassem,A Stamatoullas,L Mannone,H Dombret,K Bourgeois,P Greenberg,P Fenaux,F Dreyfus, ,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Blood

VOLUME: 111

Page Numbers: 574-82

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 16

MONTH: 10

YEAR: 2007

Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience.

AFFILIATION:

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Blood

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience Related Publications

• Antenatal sonographic features of aneurysmal dilatation of a vitelline vein.
• CHEMICAL DISINFECTION OF EXCRETA.
• Chemotactic control of the two flagellar systems of Rhodobacter sphaeroides is mediated by different sets of CheY and FliM proteins.
• Current Status of Off-pump Coronary Artery Bypass Surgery.
• Current status of bosentan for treatment of pulmonary hypertension.
• Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons.
• FURTHER OBSERVATIONS ON CHEMISTRY OF DISINFECTANTS.
• Handwritten digit recognition by neural networks with single-layer training.
• Immunoglobulin production in lymphoma cells: an immunoelectron microscopy study.
• Impact of Off-Pump Coronary Artery Bypass surgery on Post-operative Pulmonary Dysfunction: Current Best Available Evidence.
• Mitogen-activated protein kinase pathway mediates effects of brain-derived neurotrophic factor on differentiation of basal forebrain oligodendrocytes.
• Notes on the early history of leukemia.
• Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience.
• REVIEW OF FORMALDEHYDE FUMIGATION.
• The DDE recombinases: diverse roles in acquired and innate immunity.
• The flagellar muramidase from the photosynthetic bacterium Rhodobacter sphaeroides.
• Training recurrent neural networks: why and how? An illustration in dynamical process modeling.
• [Atypical abdominal pain in the first trimester of pregnancy.]
• [Bandaging of amputation stumps of the lower extremities]
• [Bandaging of the lower leg amputation stump]
• [DETERMINATION OF ERYTHROCYTE GLUTATHIONE BY AN AROMATIC NITRO DISULFIDE: 5,5'-DITHIOBIS-(2-NITROBENZOIC) ACID.]
• [Existence of UDP galactose: galactosyltransferase activity at the external surface of cultured neurons]
• [Management of postterm pregnancies.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Senescence and arthrosis]
• [Technic of applying a plaster cast]
• [Two cases of multiple sclerosis treated by phenothiazine derivatives.]