Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C.

Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C. Research Abstract Details 

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Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C. Abstract Text:

Joonho Yoon,Jong-In Lee,Soon-Koo Baik,Kwang-Ho Lee,Joon-Hyung Sohn,Hyean-Woo Lee,Jun Namkung,Sei-Jin Chang,Jong-Whan Choi,Hyun-Won Kim,Byung-Il Yeh,Joonho Yoon,Jong In Lee,Soon Koo Baik,Kwang Ho Lee,Joon Hyung Sohn,Hyean Woo Lee,Jun Namkung,Sei Jin Chang,Jong Whan Choi,Hyun Won Kim,Byung-Il Yeh,

AIM: To confirm the predictive factors for interferon (IFN)-alpha and ribavirin combination therapy for chronic hepatitis patients with hepatitis C virus (HCV) genotype 1b. METHODS: HCV RNA from 50 patients infected with HCV genotype 1b was studied by cloning and sequencing of interferon sensitivity determining region (ISDR), PKR-eIF2alpha phosphorylation homology domain (PePHD). Patients were treated with IFN-alpha and ribavirin for 6 mo and grouped by effectiveness of the therapy. A variety of factors were analyzed. RESULTS: Our data showed that age, HCV RNA titer, and ISDR type could be used as the predictive factors for combined IFN-alpha and ribavirin efficacy. Characteristically, mutations in PePHD appeared only when the combination therapy was effective. Other factors, such as sex and alanine aminotransferase (ALT) level, were not related to its efficacy. Adjusting for age and HCV RNA titer indicated that the ISDR type was the most potent predictive factor. CONCLUSION: HCV RNA ISDR type is an important factor for predicting efficacy of IFN-alpha and ribavirin combination therapy in Korean patients.

Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C. Publishing Authors By Initials

J Yoon,JI Lee,SK Baik,KH Lee,JH Sohn,HW Lee,J Namkung,SJ Chang,JW Choi,HW Kim,BI Yeh,J Yoon,JI Lee,SK Baik,KH Lee,JH Sohn,HW Lee,J Namkung,SJ Chang,JW Choi,HW Kim,BI Yeh,

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Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: World journal of gastroenterology : WJG

VOLUME: 13

Page Numbers: 6236-42

Journal Abbreviation: World J. Gastroenterol.

ISSN: 1007-9327

DAY: 14

MONTH: Dec

YEAR: 2007

Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C. Information

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LANGUAGE: eng

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AFFILIATION: Department of Biochemistry, Wonju College of Medicine, Yonsei University, 162 Ilsandong, Wonju, Gangwondo 220-701, Republic of Korea. biyeh64@hotmail.com.

Country: China

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MEDLINETA: World J Gastroenterol

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