Prediction of peptide-MHC binding using profiles.

Prediction of peptide-MHC binding using profiles. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Prediction of peptide-MHC binding using profiles. Abstract Text:

Prediction of peptide binding to major histocompatibility complex (MHC) molecules is a basis for anticipating T-cell epitopes. Peptides that bind to a given MHC molecule are related by sequence similarity. Therefore, a position-specific scoring matrix (PSSM)---also known as profile--derived from a set of aligned peptides known to bind to a given MHC molecule can be used as a predictor of both peptide-MHC binding and T-cell epitopes. In this approach, the binding potential of any peptide sequence (query) to the MHC molecule is determined by its similarity to a set of known peptide-MHC binders and can be obtained by comparing the query to the PSSM. Following structural considerations of the peptide-MHC interaction, we will describe here how to derive alignments and PSSMs that are suitable for the prediction of peptide-MHC binding.

Prediction of peptide-MHC binding using profiles. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Prediction of peptide-MHC binding using profiles. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Methods in molecular biology (Clifton, N.J.)

VOLUME: 409

Page Numbers: 185-200

Journal Abbreviation: Methods Mol. Biol.

ISSN: 1064-3745

DAY: 2

MONTH: 05

YEAR: 2007

Prediction of peptide-MHC binding using profiles. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9214969

Prediction of peptide-MHC binding using profiles. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Prediction of peptide-MHC binding using profiles. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Prediction of peptide-MHC binding using profiles.

AFFILIATION: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. parecheg@med.ucm.es

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Methods Mol Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Prediction of peptide-MHC binding using profiles Related Publications

• CD8 alpha alpha homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice.
• CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications.
• Definition of MHC supertypes through clustering of MHC peptide-binding repertoires.
• HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane.
• Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state.
• Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly.
• Prediction of peptide-MHC binding using profiles.
• Proteome informatics for cancer research: from molecules to clinic.
• The hungry caterpillar: an analysis of how carbohydrates stimulate feeding in Manduca sexta.